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TMED3 [Golgi membrane]
Stable Identifier
R-HSA-6808809
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Transmembrane emp24 domain-containing protein 3, Membrane protein p24B, p24 family protein gamma-4, p24gamma4, p26
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED3 dimer [Golgi membrane] (Homo sapiens)
TMED3 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED3 dimer [Golgi membrane] (Homo sapiens)
TMED3 [Golgi membrane] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED3 dimer [Golgi membrane] (Homo sapiens)
TMED3 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED3 dimer [Golgi membrane] (Homo sapiens)
TMED3 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED3 dimer [Golgi membrane] (Homo sapiens)
TMED3 [Golgi membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED3 dimer [Golgi membrane] (Homo sapiens)
TMED3 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED3 dimer [Golgi membrane] (Homo sapiens)
TMED3 [Golgi membrane] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED3 dimer [Golgi membrane] (Homo sapiens)
TMED3 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED3 dimer [Golgi membrane] (Homo sapiens)
TMED3 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED3 dimer [Golgi membrane] (Homo sapiens)
TMED3 [Golgi membrane] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED3 dimer [Golgi membrane] (Homo sapiens)
TMED3 [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED3 dimer [Golgi membrane] (Homo sapiens)
TMED3 [Golgi membrane] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
p24 dimers [Golgi membrane] (Homo sapiens)
TMED3 dimer [Golgi membrane] (Homo sapiens)
TMED3 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y3Q3 TMED3
Gene Names
TMED3, C15orf22, UNQ5357/PRO1078
Chain
signal peptide:1-23, chain:24-217
Reference Genes
BioGPS Gene:23423 TMED3
COSMIC (genes):TMED3 TMED3
CTD Gene:23423 TMED3
dbSNP Gene:23423 TMED3
ENSEMBL:ENSG00000166557 TMED3
ENSEMBL_homo_sapiens_GENE:ENSG00000166557.14 TMED3
HGNC:28889 TMED3
KEGG Gene (Homo sapiens):23423 TMED3
Monarch:23423 TMED3
NCBI Gene:23423 TMED3
OMIM:620437 TMED3
UCSC:Q9Y3Q3 TMED3
Reference Transcript
RefSeq:NM_001330376.1 TMED3
RefSeq:NM_007364.3 TMED3
Other Identifiers
11754102_a_at
11754103_s_at
11754104_x_at
11758103_s_at
11761549_at
16803640
208837_3p_at
208837_PM_at
208837_at
23423
239115_PM_at
239115_at
242928_PM_at
242928_at
3603688
3603689
3603691
3603697
3603698
3603700
3603716
3603717
3603718
3603720
3603722
3603724
3603726
3603728
3603729
3603730
3603731
3603732
3603733
3603734
3603735
3603736
41163_at
47848_at
77502_i_at
77504_r_at
7985240
A_23_P26173
A_32_P205913
GE56393
GE876851
GO:0000139
GO:0005783
GO:0005789
GO:0005793
GO:0005794
GO:0006886
GO:0006888
GO:0007030
GO:0015031
GO:0016020
GO:0016192
GO:0030126
GO:0030133
GO:0030134
GO:0030663
GO:0031410
GO:0032580
GO:0033116
GO:0043226
HMNXSV003014758
HMNXSV003016515
HMNXSV003053396
Hs.129003.0.A1_3p_at
Hs.71608.0.A1_3p_at
ILMN_1719316
PH_hs_0019809
TC15002308.hg
g12652570_3p_at
g12652570_3p_s_at
p5690
Participates
as a component of
TMED3 dimer [Golgi membrane] (Homo sapiens)
Other forms of this molecule
TMED3 [endoplasmic reticulum membrane]
TMED3 [endoplasmic reticulum-Golgi intermediate compartment membrane]
TMED3 [transport vesicle]
Inferred To
TMED3 [Golgi membrane]
(Bos taurus)
TMED3 [Golgi membrane]
(Canis familiaris)
TMED3 [Golgi membrane]
(Gallus gallus)
TMED3 [Golgi membrane]
(Plasmodium falciparum)
TMED3 [Golgi membrane]
(Schizosaccharomyces pombe)
TMED3 [Golgi membrane]
(Sus scrofa)
empA [Golgi membrane]
(Dictyostelium discoideum)
ERP3 [Golgi membrane]
(Saccharomyces cerevisiae)
EMP24 [Golgi membrane]
(Saccharomyces cerevisiae)
emp24 [Golgi membrane]
(Schizosaccharomyces pombe)
tmed3 [Golgi membrane]
(Danio rerio)
Homologues of TMED3 [Golgi membrane]
(Dictyostelium discoideum)
Homologues of TMED3 [Golgi membrane]
(Saccharomyces cerevisiae)
Homologues of TMED3 [Golgi membrane]
(Schizosaccharomyces pombe)
ERP2 [Golgi membrane]
(Saccharomyces cerevisiae)
ERP4 [Golgi membrane]
(Saccharomyces cerevisiae)
tmed-3 [Golgi membrane]
(Caenorhabditis elegans)
empB [Golgi membrane]
(Dictyostelium discoideum)
p24-1 [Golgi membrane]
(Drosophila melanogaster)
Tmed3 [Golgi membrane]
(Mus musculus)
Tmed3 [Golgi membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001317305.1
,
NP_031390.1
OpenTargets
ENSG00000166557
GeneCards
Q9Y3Q3
HPA
ENSG00000166557-TMED3
Ensembl
ENSP00000299705
,
ENSP00000414983
,
ENST00000424155
,
ENSG00000166557
,
ENST00000299705
PRO
Q9Y3Q3
Pharos - Targets
Q9Y3Q3
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15363 TMED2
5
TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-1911531)
TMED2 [endoplasmic reticulum membrane]
(R-HSA-5689480)
TMED2 [ER to Golgi transport vesicle membrane]
(R-HSA-5689847)
TMED2 [Golgi membrane]
(R-HSA-6808804)
TMED2 [transport vesicle]
(R-HSA-6808806)
0.527
4
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