Reactome | RAB1B [transport vesicle]

RAB1B [transport vesicle]

Stable Identifier

R-HSA-6808799

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

transport vesicle

Synonyms

Ras-related protein Rab-1B

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP [transport vesicle] (Homo sapiens)
        
        RAB1 [transport vesicle] (Homo sapiens)
        
        RAB1B [transport vesicle] (Homo sapiens)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP [transport vesicle] (Homo sapiens)
        
        RAB1 [transport vesicle] (Homo sapiens)
        
        RAB1B [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP [transport vesicle] (Homo sapiens)
        
        RAB1 [transport vesicle] (Homo sapiens)
        
        RAB1B [transport vesicle] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP [transport vesicle] (Homo sapiens)
        
        RAB1 [transport vesicle] (Homo sapiens)
        
        RAB1B [transport vesicle] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP [transport vesicle] (Homo sapiens)
        
        RAB1 [transport vesicle] (Homo sapiens)
        
        RAB1B [transport vesicle] (Homo sapiens)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP [transport vesicle] (Homo sapiens)
        
        RAB1 [transport vesicle] (Homo sapiens)
        
        RAB1B [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP [transport vesicle] (Homo sapiens)
        
        RAB1 [transport vesicle] (Homo sapiens)
        
        RAB1B [transport vesicle] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP [transport vesicle] (Homo sapiens)
        
        RAB1 [transport vesicle] (Homo sapiens)
        
        RAB1B [transport vesicle] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        RAB1:GTP [transport vesicle] (Homo sapiens)
        
        RAB1 [transport vesicle] (Homo sapiens)
        
        RAB1B [transport vesicle] (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        RAB1:GTP [transport vesicle] (Homo sapiens)
        
        RAB1 [transport vesicle] (Homo sapiens)
        
        RAB1B [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        RAB1:GTP [transport vesicle] (Homo sapiens)
        
        RAB1 [transport vesicle] (Homo sapiens)
        
        RAB1B [transport vesicle] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:cargo [transport vesicle] (Homo sapiens)
        
        RAB1:GTP [transport vesicle] (Homo sapiens)
        
        RAB1 [transport vesicle] (Homo sapiens)
        
        RAB1B [transport vesicle] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H0U4 RAB1B

Gene Names

RAB1B

Chain

chain:1-201

Reference Genes

BioGPS Gene:81876 RAB1B

COSMIC (genes):RAB1B RAB1B

CTD Gene:81876 RAB1B

dbSNP Gene:81876 RAB1B

ENSEMBL:ENSG00000174903 RAB1B

HGNC:18370 RAB1B

KEGG:hsa:81876 RAB1B

Monarch:81876 RAB1B

NCBI Gene:81876 RAB1B

OMIM:612565 RAB1B

UCSC:Q9H0U4 RAB1B

Reference Transcript

RefSeq:NM_030981.2 RAB1B

Other Identifiers

11716668_at

11716669_x_at

11716670_s_at

16727351

220964_PM_s_at

220964_s_at

3205561

3205562

3205563

3205564

3205565

3205566

3205568

3336075

3336080

3336081

3336082

3336085

3336086

3336087

3336088

3336089

3336090

3336091

3336092

3336093

3336095

3336096

43390_s_at

65902_at

65903_at

7941583

81876

A_23_P64090

A_33_P3329607

GE61198

GO:0000045

GO:0000139

GO:0000166

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005737

GO:0005789

GO:0005794

GO:0005829

GO:0006886

GO:0006888

GO:0006914

GO:0007030

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0016787

GO:0019068

GO:0030133

GO:0031410

GO:0033116

GO:0034045

GO:0043226

GO:0048471

GO:0070062

GO:0098772

GO:1903020

GO:2000785

HMNXSV003029388

ILMN_1664030

ILMN_1762802

PH_hs_0015483

PH_hs_0038055

TC11000657.hg

g13569961_3p_s_at

Participates

as a member of

RAB1 [transport vesicle] (Homo sapiens)

Other forms of this molecule

RAB1B [endoplasmic reticulum membrane]

GGC-RAB1B [transport vesicle membrane]

GGC-RAB1B [cytosol]

RAB1B [endoplasmic reticulum-Golgi intermediate compartment membrane]

RAB1B [cytosol]

RAB1B [Golgi membrane]

p-T191-RAB1B [Golgi membrane]

Inferred To

Rab1 [transport vesicle] (Drosophila melanogaster)

rabW [transport vesicle] (Dictyostelium discoideum)

rab1ba [transport vesicle] (Danio rerio)

RabX6 [transport vesicle] (Drosophila melanogaster)

rab1E [transport vesicle] (Dictyostelium discoideum)

rsmM [transport vesicle] (Dictyostelium discoideum)

rab1bb [transport vesicle] (Danio rerio)

Homologues of RAB1B [transport vesicle] (Danio rerio)

Homologues of RAB1B [transport vesicle] (Dictyostelium discoideum)

Homologues of RAB1B [transport vesicle] (Drosophila melanogaster)

Homologues of RAB1B [transport vesicle] (Saccharomyces cerevisiae)

RAB1B [transport vesicle] (Bos taurus)

RAB1B [transport vesicle] (Canis familiaris)

RAB1B [transport vesicle] (Danio rerio)

RAB1B [transport vesicle] (Dictyostelium discoideum)

RAB1B [transport vesicle] (Mus musculus)

RAB1B [transport vesicle] (Plasmodium falciparum)

RAB1B [transport vesicle] (Rattus norvegicus)

RAB1B [transport vesicle] (Saccharomyces cerevisiae)

RAB1B [transport vesicle] (Schizosaccharomyces pombe)

rab-1 [transport vesicle] (Caenorhabditis elegans)

rab1ab [transport vesicle] (Danio rerio)

Cross References

RefSeq

NP_112243.1

ENSEMBL

ENST00000311481, ENSP00000310226

OpenTargets

ENSG00000174903

HPA

ENSG00000174903-RAB1B

PRO

Q9H0U4

Pharos - Targets

Q9H0U4

GlyGen

Q9H0U4

HMDB Protein

HMDBP08509

PDB

6SKU, 5SZH, 5O74, 3JZA, 3NKV, 8ALK, 4I1O, 4HLQ, 5SZK

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.59	5
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.547	2
UniProt:Q92696 RABGGTA	2	RABGGTA [plasma membrane] (R-HSA-6801086) RABGGTA [cytosol] (R-HSA-8870418)	0.527	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:P24386 CHM	1	CHM [cytosol] (R-HSA-6801097)	0.527	3

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