Reactome | KDELR3 [Golgi membrane]

KDELR3 [Golgi membrane]

Stable Identifier

R-HSA-6808788

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

ER lumen protein-retaining receptor 3, KDEL endoplasmic reticulum protein retention receptor 3, KDEL receptor 3, ERD2.3

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
        
        Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43731 KDELR3

Gene Names

KDELR3, ERD23

Chain

chain:1-214

Reference Genes

BioGPS Gene:11015 KDELR3

COSMIC (genes):KDELR3 KDELR3

CTD Gene:11015 KDELR3

dbSNP Gene:11015 KDELR3

ENSEMBL:ENSG00000100196.11 KDELR3

HGNC:6306 KDELR3

KEGG Gene (Homo sapiens):11015 KDELR3

Monarch:11015 KDELR3

NCBI Gene:11015 KDELR3

OMIM:619900 KDELR3

UCSC:O43731 KDELR3

Reference Transcript

Other Identifiers

0002350575

0004210280

0006400239

11015

11719002_at

11730045_a_at

16930066

204017_PM_at

204017_at

207264_PM_at

207264_at

207265_PM_s_at

207265_s_at

33402_at

3945315

3945316

3945318

3945319

3945320

3945321

3945322

3945323

3945324

3945325

3945326

3945327

3945328

3945329

3945330

8073015

A_14_P128501

A_23_P211504

GE62782

GE82156

GO:0000139

GO:0005046

GO:0005515

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005801

GO:0006621

GO:0006888

GO:0006890

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0030133

GO:0030663

GO:0031410

GO:0043226

GO:0046923

HMNXSV003049937

ILMN_1713901

ILMN_1722820

ILMN_1798952

TC22000301.hg

g8051610_3p_a_at

g8051612_3p_at

Participates

as a member of

Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)

as a candidate of

ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)

Other forms of this molecule

KDELR3 [endoplasmic reticulum membrane]

KDELR3 [endoplasmic reticulum-Golgi intermediate compartment membrane]

KDELR3 [transport vesicle]

Inferred To

erd2 [Golgi membrane] (Schizosaccharomyces pombe)

KDELR3 [Golgi membrane] (Bos taurus)

KDELR3 [Golgi membrane] (Canis familiaris)

KDELR3 [Golgi membrane] (Gallus gallus)

KDELR3 [Golgi membrane] (Rattus norvegicus)

KDELR3 [Golgi membrane] (Sus scrofa)

erd-2.1 [Golgi membrane] (Caenorhabditis elegans)

kdelr3 [Golgi membrane] (Danio rerio)

kdelr3 [Golgi membrane] (Xenopus tropicalis)

KdelR [Golgi membrane] (Drosophila melanogaster)

ERD2 [Golgi membrane] (Plasmodium falciparum)

ERD2 [Golgi membrane] (Saccharomyces cerevisiae)

Kdelr3 [Golgi membrane] (Mus musculus)

kdelr [Golgi membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_057839.1, NP_006846.1

OpenTargets

ENSG00000100196

HPA

ENSG00000100196-KDELR3

GeneCards

O43731

Ensembl

ENSP00000216014, ENST00000409006, ENST00000216014, ENSG00000100196, ENSP00000386918

PRO

O43731

Pharos - Targets

O43731

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