Reactome | KDELR3 [Golgi membrane]

KDELR3

Stable Identifier

R-HSA-6808788

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

ER lumen protein-retaining receptor 3, KDEL endoplasmic reticulum protein retention receptor 3, KDEL receptor 3, ERD2.3

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
        
        Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        Golgi-to-ER cargo [Golgi membrane] (Homo sapiens)
        
        KDELR3 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43731 KDELR3

Gene Names

KDELR3

Chain

chain:1-214

Reference Genes

BioGPS Gene:11015 KDELR3

COSMIC (genes):KDELR3 KDELR3

CTD Gene:11015 KDELR3

dbSNP Gene:11015 KDELR3

ENSEMBL:ENSG00000100196 KDELR3

HGNC:6306 KDELR3

KEGG Gene (Homo sapiens):hsa:11015 KDELR3

Monarch:11015 KDELR3

NCBI Gene:11015 KDELR3

UCSC:O43731 KDELR3

Reference Transcript

Other Identifiers

0002350575

0004210280

0006400239

11015

11719002_at

11730045_a_at

16930066

204017_at

207264_at

207265_s_at

33402_at

3945315

3945316

3945318

3945319

3945320

3945321

3945322

3945323

3945324

3945325

3945326

3945327

3945328

3945329

43477

76405

8073015

A0A024R1R0

A_14_P128501

A_23_P211504

AAH01277

AAH96722

AAH98131

AAH98156

AAH98336

AK222930

AK223238

AK292102

AL035081

AL035082

BAD96650

BAD96958

BAF84791

BC001277

BC096722

BC098131

BC098156

BC098336

CAA22673

CAA22674

CAG30395

CCDS13972

CCDS46705

CH471095

CR456509

EAW60237

EAW60238

EAW60240

ENSG00000100196

ENSP00000216014

ENSP00000386918

ENST00000216014

ENST00000409006

EntrezGene:11015

g8051610_3p_a_at

g8051612_3p_at

GE62782

GE82156

GO:0000139

GO:0003674

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0006621

GO:0006810

GO:0006890

GO:0006950

GO:0007165

GO:0008150

GO:0015031

GO:0016020

GO:0016021

GO:0016192

GO:0030133

GO:0031410

GO:0036498

GO:0043226

GO:0046923

HGNC:6306

HPA043477

HPA076405

ILMN_1713901

ILMN_1722820

ILMN_1798952

IPR000133

KDELR3

KDELR3-201

KDELR3-202

NM_006855

NM_016657

NP_006846

NP_057839

PF00810

PR00660

TC22000301.hg

uc003avu.5

uc003avv.4

UPI000012A0CD

UPI00001614FD

Z97056

Participant Of

hasCandidate

ERGIC-to-cis-Golgi cargo [Golgi membrane]

hasMember

Golgi-to-ER cargo [Golgi membrane]

Other forms of this molecule

KDELR3 [endoplasmic reticulum membrane]

KDELR3 [endoplasmic reticulum-Golgi intermediate compartment membrane]

KDELR3 [transport vesicle]

Inferred To

Homologues of KDELR3 [Golgi membrane] (Arabidopsis thaliana)

Homologues of KDELR3 [Golgi membrane] (Caenorhabditis elegans)

Homologues of KDELR3 [Golgi membrane] (Danio rerio)

Homologues of KDELR3 [Golgi membrane] (Gallus gallus)

Homologues of KDELR3 [Golgi membrane] (Oryza sativa)

Homologues of KDELR3 [Golgi membrane] (Rattus norvegicus)

KDELR3 [Golgi membrane] (Arabidopsis thaliana)

KDELR3 [Golgi membrane] (Bos taurus)

KDELR3 [Golgi membrane] (Caenorhabditis elegans)

KDELR3 [Golgi membrane] (Canis familiaris)

KDELR3 [Golgi membrane] (Danio rerio)

KDELR3 [Golgi membrane] (Dictyostelium discoideum)

KDELR3 [Golgi membrane] (Drosophila melanogaster)

KDELR3 [Golgi membrane] (Gallus gallus)

KDELR3 [Golgi membrane] (Mus musculus)

KDELR3 [Golgi membrane] (Oryza sativa)

KDELR3 [Golgi membrane] (Plasmodium falciparum)

KDELR3 [Golgi membrane] (Rattus norvegicus)

KDELR3 [Golgi membrane] (Saccharomyces cerevisiae)

KDELR3 [Golgi membrane] (Schizosaccharomyces pombe)

KDELR3 [Golgi membrane] (Sus scrofa)

KDELR3 [Golgi membrane] (Taeniopygia guttata)

KDELR3 [Golgi membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_057839.1, NP_006846.1

GeneCards

O43731

PRO

O43731