Reactome | GPI-CD55 [transport vesicle]

GPI-CD55 [transport vesicle]

Stable Identifier

R-HSA-6808771

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

transport vesicle

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
        
        GPI-CD55 [transport vesicle] (Homo sapiens)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
        
        GPI-CD55 [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
        
        GPI-CD55 [transport vesicle] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
        
        ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)
        
        GPI-CD55 [transport vesicle] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
17927562	Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane Kinoshita, T, Maeda, Y, Takida, S	Biochem. J.	2008

External Reference Information

External Reference

UniProt:P08174 CD55

Gene Names

CD55, CR, DAF

Chain

signal peptide:1-34, chain:35-353, propeptide:354-381

Reference Genes

BioGPS Gene:1604 CD55

COSMIC (genes):CD55 CD55

CTD Gene:1604 CD55

dbSNP Gene:1604 CD55

ENSEMBL:ENSG00000196352 CD55

ENSEMBL:ENSG00000196352.18 CD55

HGNC:2665 CD55

KEGG Gene (Homo sapiens):1604 CD55

Monarch:1604 CD55

NCBI Gene:1604 CD55

OMIM:125240 CD55

UCSC:P08174 CD55

Reference Transcript

Other Identifiers

11728701_a_at

11746180_a_at

11752832_x_at

11755084_x_at

11762060_x_at

11762726_x_at

1555950_3p_a_at

1555950_PM_a_at

1555950_a_at

1604

16676764

201925_PM_s_at

201925_s_at

201926_PM_s_at

201926_s_at

2377230

2377231

2377232

2377236

2377239

2377241

2377242

2377245

2377247

2377255

2377258

2377262

2377268

2377269

2377270

2377271

2377272

39695_at

7909332

A_14_P119189

A_14_P201810

A_23_P374862

A_24_P188377

GE61268

GO:0000139

GO:0001618

GO:0002376

GO:0002726

GO:0005515

GO:0005576

GO:0005615

GO:0005794

GO:0005886

GO:0006958

GO:0007155

GO:0007204

GO:0008289

GO:0009986

GO:0016020

GO:0023052

GO:0030133

GO:0030449

GO:0030667

GO:0031410

GO:0031664

GO:0033116

GO:0043226

GO:0045087

GO:0045121

GO:0045730

GO:0045916

GO:0046718

GO:0070062

GO:0098542

GO:0101003

GO:1903659

GO:2000516

GO:2000563

HMNXSV003018773

ILMN_1800540

M31516_s_at

PH_hs_0024773

TC01001736.hg

g10835142_3p_a_at

g12654888_3p_a_at

Participates

as a member of

ERGIC-to-cis-Golgi cargo [transport vesicle] (Homo sapiens)

Other forms of this molecule

CD55 [extracellular region]

CD55 [ficolin-1-rich granule membrane]

CD55 [secretory granule membrane]

GPI-CD55 [Golgi membrane]

GPI-CD55 [endoplasmic reticulum-Golgi intermediate compartment membrane]

CD55 [plasma membrane]

Inferred To

GPI-CD55 [transport vesicle] (Canis familiaris)

GPI-CD55 [transport vesicle] (Gallus gallus)

GPI-CD55 [transport vesicle] (Rattus norvegicus)

GPI-CD55 [transport vesicle] (Sus scrofa)

hig [transport vesicle] (Drosophila melanogaster)

CD55 [transport vesicle] (Bos taurus)

Cd55 [transport vesicle] (Mus musculus)

Modified Residues

Name

L-serine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 353

Coordinate

353

Modification

GPI-anchor amidated amino acid carboxyl end residue(1−)

PsiMod Name

L-serine amide

PsiMod Definition

A protein modification that effectively converts an L-serine residue to L-serine amide.

Cross References

RefSeq

NP_000565.1, NP_001287832.1, NP_001108224.1, NP_001287833.1

OpenTargets

ENSG00000196352

GeneCards

P08174

HPA

ENSG00000196352-CD55

Ensembl

ENST00000644836, ENSP00000496251, ENSP00000495518, ENSP00000356031, ENSG00000196352, ENST00000367064, ENST00000314754, ENSP00000316333, ENST00000645323

PRO

P08174

Pharos - Targets

P08174

PDB

1UOT, 1OJW, 7DO4, 1OK1, 1M11, 6ILJ, 1H03, 1H04, 6ILK, 3IYP, 2QZH, 1OJV, 7C9W, 6LA5, 1OK3, 1OK2, 2C8I, 1OJY, 1NWV, 1H2P, 1OK9, 5FOA, 2QZF, 7VY6, 1H2Q, 7VY5, 2QZD, 1UPN, 3J24

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