CHGA-derived peptide binds the bacterial cell surface

Stable Identifier
R-HSA-6808566
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Chromogranin A (CHGA) belongs to the granin family of acidic proteins enclosed in secretory vesicles of nervous, endocrine and immune cells. The proteolytic cleveages of specific CHGA sequences by the pro-hormone convertases generate bioactive fragments that exert a broad spectrum of regulatory activities by influencing the endocrine, cardiovascular and immune systems and affect glucose and calcium homeostasis (Helle KB et al. 2007; Aslam R et al. 2012; D'amico MA et al. 2014; Aung G et al. 2011; Tota B et al. 2014).

Several CHGA-derived peptides such as vasostatin-1 (CHGA(19-94) ) and catestatin (CHGA(370-390)) display antimicrobial activities against bacteria, fungi and yeasts (Lugardon K et al. 2000; Briolat J et al. 2005; Radek KA et al. 2008; Aslam R et al. 2013; Shooshtarizadeh P et al. 2010). These peptides are found in biological fluids involved in defence mechanisms (human serum and saliva) and in supernatants of stimulated human neutrophils (Lugardon K et al. 2000; Briolat J et al. 2005). In addition, catestatin (CHGA(370-390) exhibits antimicrobial activity against skin pathogens suggesting a function in cutaneous antimicrobial defense (Radek KA et al. 2008). Biophysical and structural analysis of human catestatin and bovine cateslytin suggests that cationic CHGA-derived peptides interact with anionic phospholipids on the bacterial surface (Sugawara M et al. 2010; Jean-Francois F et al. 2008). However, It remains to be clarified whether catestatin functions as a pore-forming or cell-penetrating agent.

Literature References
PubMed ID Title Journal Year
18185531 The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury

Radek, KA, Lopez-Garcia, B, Hupe, M, Niesman, IR, Elias, PM, Taupenot, L, Mahata, SK, O'Connor, DT, Gallo, RL

J. Invest. Dermatol. 2008
20103720 Membrane structure and interactions of human catestatin by multidimensional solution and solid-state NMR spectroscopy

Sugawara, M, Resende, JM, Moraes, CM, Marquette, A, Chich, JF, Metz-Boutigue, MH, Bechinger, B

FASEB J. 2010
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!