Reactome | LDHAL6B reduces PYR to LACT

LDHAL6B reduces PYR to LACT

Stable Identifier

R-HSA-6807826

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

LDHAL6B (L-lactate dehydrogenase A-like 6B) catalyzes the reaction of PYR (pyruvate) and NADH + H+ to form LACT (lactate) and NAD+. The LDHAL6B protein is the inferred product of an open reading frame transcribed in the testis (Wang et al. 2005). Its mitochondrial localization is inferred from the presence of a mitochondrial localization sequence at its amino terminus (Holmes and Goldberg 2009). A physiological role for lactate formation from the abundant pyruvate and NADH expected in rapidly respiring mitochondria is not straightforward to imagine, however.

Literature References

PubMed ID	Title	Journal	Year
19679512	Computational analyses of mammalian lactate dehydrogenases: human, mouse, opossum and platypus LDHs Holmes, RS, Goldberg, E	Comput Biol Chem	2009
15870898	Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testis Wang, H, Sha, J, Xu, Z, Zhou, Z, Lu, L	Int. J. Mol. Med.	2005