POU2F1 (OCT1) or POU2F2 (OCT2), SP1, and ZNF143 (STAF) bind the DSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)

Stable Identifier
Reaction [binding]
Homo sapiens
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An octamer binding factor, POU2F1 (Oct-1) or POU2F2 (Oct-2), SP1, ZNF143 (Staf) and possibly other transcription factors bind the distal sequence element (DSE) in the promoter of the snRNA gene (Murphy et al. 1992, Strom et al. 1996, Murphy 1997, Hovde et al. 2002). These upstream transcription factors enhance subsequent binding of the SNAPc complex to the downstream proximal sequence element (PSE) of the promoter.

Literature References
PubMed ID Title Journal Year
11856838 Crystallization of the Oct-1/SNAP190 peptide/DNA complex

Hovde, S, Brooks, A, Strong, K, Geiger, JH

Acta Crystallogr. D Biol. Crystallogr. 2002
1535687 Oct-1 and Oct-2 potentiate functional interactions of a transcription factor with the proximal sequence element of small nuclear RNA genes

Yoon, JB, Gerster, T, Murphy, S, Roeder, RG

Mol Cell Biol 1992
9705341 ZNF76 and ZNF143 are two human homologs of the transcriptional activator Staf

Myslinski, E, Krol, A, Carbon, P

J Biol Chem 1998
1739980 Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter

Tanaka, M, Lai, JS, Herr, W

Cell 1992
12414730 Activator recruitment by the general transcription machinery: X-ray structural analysis of the Oct-1 POU domain/human U1 octamer/SNAP190 peptide ternary complex

Hovde, S, Henry, RW, Gu, L, Brooks, A, Hinkley, CS, Strong, K, Geiger, J

Genes Dev. 2002
8668525 The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression

Westin, G, Lillhager, P, Ström, AC, Forsberg, M

Nucleic Acids Res. 1996
9153304 Differential in vivo activation of the class II and class III snRNA genes by the POU-specific domain of Oct-1

Murphy, S

Nucleic Acids Res. 1997
9009278 Staf, a promiscuous activator for enhanced transcription by RNA polymerases II and III

Schuster, C, Schaub, M, Myslinski, E, Krol, A, Carbon, P

EMBO J. 1997
1829677 Both Oct-1 and Oct-2A contain domains which can activate the ubiquitously expressed U2 snRNA genes

Schaffner, W, Westin, G, Müller-Immerglück, MM, Yang, J, Seipel, K, Pettersson, U, Janson, L

EMBO J. 1991
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