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ICE1 [nucleoplasm]
Stable Identifier
R-HSA-6807433
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Little elongation complex subunit 1, ICE1_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ICE1 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ICE1 [nucleoplasm] (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ICE1 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ICE1 [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ICE1 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ICE1 [nucleoplasm] (Homo sapiens)
Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ICE1 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ICE1 [nucleoplasm] (Homo sapiens)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ICE1 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Homo sapiens)
LEC [nucleoplasm] (Homo sapiens)
ICE1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2F5 ICE1
Gene Names
ICE1, KIAA0947
Chain
chain:1-2266
Reference Genes
BioGPS Gene:23379 ICE1
COSMIC (genes):ICE1 ICE1
CTD Gene:23379 ICE1
dbSNP Gene:23379 ICE1
ENSEMBL:ENSG00000164151 ICE1
ENSEMBL_homo_sapiens_GENE:ENSG00000164151.12 ICE1
HGNC:29154 ICE1
KEGG Gene (Homo sapiens):23379 ICE1
Monarch:23379 ICE1
NCBI Gene:23379 ICE1
OMIM:617958 ICE1
UCSC:Q9Y2F5 ICE1
Reference Transcript
RefSeq:NM_015325.2 ICE1
Other Identifiers
11743303_a_at
16982898
209654_PM_at
209654_at
23379
2800139
2800140
2800141
2800143
2800144
2800147
2800148
2800149
2800151
2800152
2800153
2800154
2800155
2800156
2800157
2800159
2800160
2800161
2800162
2800163
2800164
2800165
2800166
2800170
2800172
2800173
2800175
2800176
2800177
41595_at
8104350
A_32_P35800
GE53618
GO:0000791
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006351
GO:0006355
GO:0006886
GO:0008023
GO:0015030
GO:0016073
GO:0016604
GO:0030674
GO:0031334
GO:0035363
GO:0042795
GO:0042796
GO:0043226
GO:0045945
GO:0060090
GO:0065003
GO:0090316
HMNXSV003057639
ILMN_1772658
PH_hs_0000521
TC05000040.hg
g13436178_3p_at
Participates
as a component of
LEC [nucleoplasm] (Homo sapiens)
Inferred To
ice1 [nucleoplasm]
(Danio rerio)
Ice1 [nucleoplasm]
(Mus musculus)
Ice1 [nucleoplasm]
(Rattus norvegicus)
Paf-AHalpha [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of ICE1 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of ICE1 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of ICE1 [nucleoplasm]
(Xenopus tropicalis)
ICE1 [nucleoplasm]
(Bos taurus)
ICE1 [nucleoplasm]
(Canis familiaris)
ICE1 [nucleoplasm]
(Gallus gallus)
ICE1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_056140.1
OpenTargets
ENSG00000164151
HPA
ENSG00000164151-ICE1
GeneCards
Q9Y2F5
Ensembl
ENSG00000164151
,
ENSP00000296564
,
ENST00000296564
PRO
Q9Y2F5
Pharos - Targets
Q9Y2F5
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.643
6
UniProt:P55199 ELL
1
ELL [nucleoplasm]
(R-HSA-54257)
0.623
4
UniProt:P09661 SNRPA1
1
SNRPA1 [nucleoplasm]
(R-HSA-71958)
0.527
2
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