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3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-6807218
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
gamma-carboxy-proBGLAP, gamma-carboxy-pro-Bone Gla protein, gamma-carboxy-proOCN, gamma-carboxy-pro-Osteocalcin
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Homo sapiens)
Gamma-carboxylation of protein precursors (Homo sapiens)
GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Homo sapiens)
3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen] (Homo sapiens)
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)
Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)
3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
6967872
Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residue
Poser, JW
,
Ling, NC
,
Price, PA
,
Esch, FS
J. Biol. Chem.
1980
External Reference Information
External Reference
UniProt:P02818 BGLAP
Gene Names
BGLAP, Osteocalcin, OC
Chain
signal peptide:1-23, propeptide:24-51, chain:52-100
Reference Genes
BioGPS Gene:632 BGLAP
COSMIC (genes):BGLAP BGLAP
CTD Gene:632 BGLAP
dbSNP Gene:632 BGLAP
ENSEMBL:ENSG00000242252 BGLAP
ENSEMBL_homo_sapiens_GENE:ENSG00000242252.2 BGLAP
HGNC:1043 BGLAP
KEGG Gene (Homo sapiens):632 BGLAP
Monarch:632 BGLAP
NCBI Gene:632 BGLAP
OMIM:112260 BGLAP
UCSC:P02818 BGLAP
Reference Transcript
RefSeq:NM_199173.5 BGLAP
Other Identifiers
11728535_at
206956_PM_at
206956_at
2361425
2361427
2361428
2361430
2361431
2361432
2361433
36253_at
632
7906140
A_23_P160638
A_24_P336551
A_33_P3323481
GE80940
GO:0001501
GO:0001503
GO:0001649
GO:0001956
GO:0002076
GO:0002376
GO:0005179
GO:0005198
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0006629
GO:0007155
GO:0007165
GO:0007420
GO:0007611
GO:0008147
GO:0009410
GO:0009612
GO:0009629
GO:0010035
GO:0010043
GO:0014070
GO:0014823
GO:0016311
GO:0023052
GO:0030154
GO:0030282
GO:0030425
GO:0030500
GO:0031214
GO:0031667
GO:0031982
GO:0032571
GO:0032868
GO:0032869
GO:0033280
GO:0033574
GO:0033594
GO:0034224
GO:0036005
GO:0042593
GO:0042995
GO:0043204
GO:0043226
GO:0043627
GO:0044342
GO:0045124
GO:0045471
GO:0045670
GO:0046848
GO:0046872
GO:0048018
GO:0048731
GO:0048856
GO:0048863
GO:0050877
GO:0050890
GO:0051384
GO:0060348
GO:0071305
GO:0071363
GO:0098772
GO:1900076
GO:1903011
GO:2000224
HMNXSV003018069
ILMN_1755818
X04143_at
g4502400_3p_at
Participates
as an input of
Gamma-carboxy pro-BGLAP transport from the endoplasmic reticulum to the Golgi apparatus (Homo sapiens)
as an output of
GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) (Homo sapiens)
Other forms of this molecule
BGLAP(24-51) [Golgi lumen]
3xCbxE-BGLAP(52-100) [Golgi lumen]
3xCbxE-BGLAP(24-100) [Golgi lumen]
BGLAP(24-100) [endoplasmic reticulum lumen]
Inferred To
3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen]
(Bos taurus)
3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen]
(Canis familiaris)
3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen]
(Danio rerio)
3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen]
(Gallus gallus)
3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen]
(Mus musculus)
3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen]
(Rattus norvegicus)
3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen]
(Sus scrofa)
3xCbxE-BGLAP(24-100) [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Modified Residues
Name
L-gamma-carboxyglutamic acid at 68
Coordinate
68
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 72
Coordinate
72
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 75
Coordinate
75
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Cross References
RefSeq
NP_954642.1
OpenTargets
ENSG00000242252
GeneCards
P02818
HPA
ENSG00000242252-BGLAP
Ensembl
ENSP00000357255
,
ENST00000368272
,
ENSG00000242252
PRO
P02818
Pharos - Targets
P02818
HMDB Protein
HMDBP02008
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12797-6 ASPH
0.556
3
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