Reactome | GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)

GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)

Stable Identifier

R-HSA-6807214

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

Synonyms

pro-osteocalciin, uncarboxylated + 3 CO2 + 3 O2 + 3 vitamin K hydroquinone -> gamma-carboxylated pro-osteocalcin + 3 H2O + 3 vitamin K epoxide

ReviewStatus

5/5

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GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)

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GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates three glutamate residues on BGLAP(24-100) (pro-osteocalcin). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process (Berkner 2000; Ferron et al. 2015; Furie et al. 1999; Hauschka et al. 1989; Morris et al. 1995; oser et al. 1980; Stenina et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
10068650	Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid Furie, B, Bouchard, BA, Furie, BC	Blood	1999
10917896	The vitamin K-dependent carboxylase Berkner, KL	J Nutr	2000
6967872	Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residue Poser, JW, Esch, FS, Ling, NC, Price, PA	J. Biol. Chem.	1980
2664828	Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone Hauschka, PV, Lian, JB, Cole, DE, Gundberg, CM	Physiol. Rev.	1989
8530480	Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate. Morris, DP, Stevens, RD, Wright, DJ, Stafford, DW	J Biol Chem	1995
25753038	GGCX and VKORC1 inhibit osteocalcin endocrine functions Ferron, M, Lacombe, J, Germain, A, Oury, F, Karsenty, G	J. Cell Biol.	2015
11513608	Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo Stenina, O, Pudota, BN, McNally, BA, Hommema, EL, Berkner, KL	Biochemistry	2001