GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)

Stable Identifier
R-HSA-6807214
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
pro-osteocalciin, uncarboxylated + 3 CO2 + 3 O2 + 3 vitamin K hydroquinone -> gamma-carboxylated pro-osteocalcin + 3 H2O + 3 vitamin K epoxide
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates three glutamate residues on BGLAP(24-100) (pro-osteocalcin). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process (Berkner 2000; Ferron et al. 2015; Furie et al. 1999; Hauschka et al. 1989; Morris et al. 1995; oser et al. 1980; Stenina et al. 2001).

Literature References
PubMed ID Title Journal Year
10917896 The vitamin K-dependent carboxylase

Berkner, KL

J Nutr 2000
10068650 Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid

Furie, B, Bouchard, BA, Furie, BC

Blood 1999
6967872 Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residue

Poser, JW, Esch, FS, Ling, NC, Price, PA

J. Biol. Chem. 1980
2664828 Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone

Hauschka, PV, Lian, JB, Cole, DE, Gundberg, CM

Physiol. Rev. 1989
8530480 Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate.

Morris, DP, Stevens, RD, Wright, DJ, Stafford, DW

J Biol Chem 1995
25753038 GGCX and VKORC1 inhibit osteocalcin endocrine functions

Ferron, M, Lacombe, J, Germain, A, Oury, F, Karsenty, G

J. Cell Biol. 2015
11513608 Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo

Stenina, O, Pudota, BN, McNally, BA, Hommema, EL, Berkner, KL

Biochemistry 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
gamma-glutamyl carboxylase activity of GGCX [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created