USP13 and OTUD3 deubiquitinate PTEN

Stable Identifier
R-HSA-6807206
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Several ubiquitin proteases deubiquitinate polyubiquitinated PTEN. USP13 and OTUD3 prolong the half-life of PTEN by preventing its proteasome-mediated degradation. Loss of USP13 or OTUD3 expression promotes AKT activation and cancer aggressiveness (Zhang et al. 2013, Yuan et al. 2015).

Literature References
PubMed ID Title Journal Year
24270891 Deubiquitylation and stabilization of PTEN by USP13

Zhang, J, Zhang, P, Wei, Y, Piao, HL, Wang, W, Maddika, S, Wang, M, Chen, D, Sun, Y, Hung, MC, Chen, J, Ma, L

Nat. Cell Biol. 2013
26280536 Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Yuan, L, Lv, Y, Li, H, Gao, H, Song, S, Zhang, Y, Xing, G, Kong, X, Wang, L, Li, Y, Zhou, T, Gao, D, Xiao, ZX, Yin, Y, Wei, W, He, F, Zhang, L

Nat. Cell Biol. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of USP13,OTUD3 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created