NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN

Stable Identifier
R-HSA-6807134
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Several ubiquitin ligases, including NEDD4 (Wang et al. 2007), STUB1 (CHIP) (Ahmed et al. 2012), WWP2 (Maddika et al. 2011) and XIAP (Van Themsche et al. 2009) can polyubiquitinate PTEN, targeting it for degradation.

Literature References
PubMed ID Title Journal Year
21532586 WWP2 is an E3 ubiquitin ligase for PTEN

Maddika, S, Kavela, S, Rani, N, Palicharla, VR, Pokorny, JL, Sarkaria, JN, Chen, J

Nat. Cell Biol. 2011
19473982 X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

Van Themsche, C, Leblanc, V, Parent, S, Asselin, E

J. Biol. Chem. 2009
22427670 The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation

Ahmed, SF, Deb, S, Paul, I, Chatterjee, A, Mandal, T, Chatterjee, U, Ghosh, MK

J. Biol. Chem. 2012
17218260 NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

Wang, X, Trotman, LC, Koppie, T, Alimonti, A, Chen, Z, Gao, Z, Wang, J, Erdjument-Bromage, H, Tempst, P, Cordon-Cardo, C, Pandolfi, PP, Jiang, X

Cell 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of NEDD4,STUB1,WWP2 and XIAP [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed