NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN

Stable Identifier
Homo sapiens
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Several ubiquitin ligases, including NEDD4 (Wang et al. 2007), STUB1 (CHIP) (Ahmed et al. 2012), WWP2 (Maddika et al. 2011) and XIAP (Van Themsche et al. 2009) can polyubiquitinate PTEN, targeting it for degradation.

Literature References
PubMed ID Title Journal Year
19473982 X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

Van Themsche, C, Parent, S, Leblanc, V, Asselin, E

J. Biol. Chem. 2009
21532586 WWP2 is an E3 ubiquitin ligase for PTEN

Pokorny, JL, Palicharla, VR, Kavela, S, Chen, J, Maddika, S, Rani, N, Sarkaria, JN

Nat. Cell Biol. 2011
22427670 The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation

Paul, I, Mandal, T, Chatterjee, U, Ahmed, SF, Ghosh, MK, Chatterjee, A, Deb, S

J. Biol. Chem. 2012
17218260 NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

Pandolfi, PP, Cordon-Cardo, C, Trotman, LC, Gao, Z, Wang, J, Chen, Z, Wang, X, Jiang, X, Koppie, T, Tempst, P, Alimonti, A, Erdjument-Bromage, H

Cell 2007
Catalyst Activity

ubiquitin protein ligase activity of NEDD4,STUB1,WWP2 and XIAP [cytosol]

Orthologous Events
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