Reactome | NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN

NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN

Stable Identifier

R-HSA-6807134

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN

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Several ubiquitin ligases, including NEDD4 (Wang et al. 2007), STUB1 (CHIP) (Ahmed et al. 2012), WWP2 (Maddika et al. 2011) and XIAP (Van Themsche et al. 2009) can polyubiquitinate PTEN, targeting it for degradation.

Literature References

PubMed ID	Title	Journal	Year
19473982	X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization Van Themsche, C, Parent, S, Leblanc, V, Asselin, E	J. Biol. Chem.	2009
21532586	WWP2 is an E3 ubiquitin ligase for PTEN Pokorny, JL, Palicharla, VR, Kavela, S, Chen, J, Maddika, S, Rani, N, Sarkaria, JN	Nat. Cell Biol.	2011
22427670	The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation Paul, I, Mandal, T, Chatterjee, U, Ahmed, SF, Ghosh, MK, Chatterjee, A, Deb, S	J. Biol. Chem.	2012
17218260	NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN Pandolfi, PP, Cordon-Cardo, C, Trotman, LC, Gao, Z, Wang, J, Chen, Z, Wang, X, Jiang, X, Koppie, T, Tempst, P, Alimonti, A, Erdjument-Bromage, H	Cell	2007