DHCR7 reduces 7-dehydroCHOL to CHOL

Stable Identifier
R-HSA-6807055
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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DHCR7 (7-dehydrocholesterol reductase) associated with the endoplasmic reticulum membrane reduces 7-dehydroCHOL (7-dehydrocholesterol) to CHOL (cholesterol) (Kandutsch & Russell1960; Mitsche et al. 2015; Moebius et al. 1998).

Literature References
PubMed ID Title Journal Year
14404284 Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol

Russell, AE, Kandutsch, AA

J. Biol. Chem. 1960
9465114 Molecular cloning and expression of the human delta7-sterol reductase

Lee, JN, Fitzky, BU, Paik, YK, Moebius, FF, Glossmann, H

Proc Natl Acad Sci U S A 1998
26114596 Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

Hobbs, HH, Mitsche, MA, Cohen, JC, McDonald, JG

Elife 2015
Participants
Participates
Catalyst Activity

7-dehydrocholesterol reductase activity of DHCR7 [endoplasmic reticulum membrane]

Orthologous Events
Cross References
Rhea
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Reviewed
Created
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