DHCR7 reduces 7-dehydroCHOL to CHOL

Stable Identifier
R-HSA-6807055
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

DHCR7 (7-dehydrocholesterol reductase) associated with the endoplasmic reticulum membrane reduces 7-dehydroCHOL (7-dehydrocholesterol) to CHOL (cholesterol) (Kandutsch & Russell1960; Mitsche et al. 2015; Moebius et al. 1998).

Literature References
PubMed ID Title Journal Year
9465114 Molecular cloning and expression of the human delta7-sterol reductase

Moebius, FF, Fitzky, BU, Lee, JN, Paik, YK, Glossmann, H

Proc Natl Acad Sci U S A 1998
14404284 Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol

Kandutsch, AA, Russell, AE

J. Biol. Chem. 1960
26114596 Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

Mitsche, MA, McDonald, JG, Hobbs, HH, Cohen, JC

Elife 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
7-dehydrocholesterol reductase activity of DHCR7 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!