Reactome | DHCR7 reduces 7-dehydroCHOL to CHOL

DHCR7 reduces 7-dehydroCHOL to CHOL

Stable Identifier

R-HSA-6807055

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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DHCR7 (7-dehydrocholesterol reductase) associated with the endoplasmic reticulum membrane reduces 7-dehydroCHOL (7-dehydrocholesterol) to CHOL (cholesterol) (Kandutsch & Russell1960; Mitsche et al. 2015; Moebius et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
14404284	Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol Russell, AE, Kandutsch, AA	J. Biol. Chem.	1960
9465114	Molecular cloning and expression of the human delta7-sterol reductase Lee, JN, Fitzky, BU, Paik, YK, Moebius, FF, Glossmann, H	Proc Natl Acad Sci U S A	1998
26114596	Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways Hobbs, HH, Mitsche, MA, Cohen, JC, McDonald, JG	Elife	2015