SC5D desaturates LTHSOL to 7-dehydroCHOL

Stable Identifier
R-HSA-6807053
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SC5D (lathosterol oxidase) associated with the endoplasmic reticulum desaturates LTHSOL (lathosterol) to 7-dehydroCHOL (7-dehydrocholesterol) (Brunetti-Pierri et al. 2002; Kandutsch & Russell 1960; Krakowiek et al. 2003; Mitsche et al. 2015).

Literature References
PubMed ID Title Journal Year
14404284 Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol

Kandutsch, AA, Russell, AE

J. Biol. Chem. 1960
12189593 Lathosterolosis, a novel multiple-malformation/mental retardation syndrome due to deficiency of 3beta-hydroxysteroid-delta5-desaturase

Brunetti-Pierri, N, Corso, G, Rossi, M, Ferrari, P, Balli, F, Rivasi, F, Annunziata, I, Ballabio, A, Dello Russo, A, Andria, G, Parenti, G

Am J Hum Genet 2002
26114596 Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

Mitsche, MA, McDonald, JG, Hobbs, HH, Cohen, JC

Elife 2015
12812989 Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency

Krakowiak, PA, Wassif, CA, Kratz, L, Cozma, D, Kovarova, M, Harris, G, Grinberg, A, Yang, Y, Hunter, AG, Tsokos, M, Kelley, RI, Porter, FD

Hum Mol Genet 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
C-5 sterol desaturase activity of SC5D [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!