Reactome | UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)

UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)

Stable Identifier

R-HSA-6806674

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

ReviewStatus

5/5

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UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)

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UBIAD1 (UbiA prenyltransferase domain-containing protein 1) in the endoplasmic reticulum catalyzes the transfer of a geranylgeranyl group from GGPP (geranylgeranyl pyrophosphate)to menadione to form MK4 (vitamin K hydroquinone, menatetrenone) (Nakagawa et al. 2010; Hirota et al. 2013, 2015; Schumacher et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
24085302	Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats Hirota, Y, Tsugawa, N, Nakagawa, K, Suhara, Y, Tanaka, K, Uchino, Y, Takeuchi, A, Sawada, N, Kamao, M, Wada, A, Okitsu, T, Okano, T	J. Biol. Chem.	2013
25742604	The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase Schumacher, MM, Elsabrouty, R, Seemann, J, Jo, Y, DeBose-Boyd, RA	Elife	2015
25874989	Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1 Hirota, Y, Nakagawa, K, Sawada, N, Okuda, N, Suhara, Y, Uchino, Y, Kimoto, T, Funahashi, N, Kamao, M, Tsugawa, N, Okano, T	PLoS ONE	2015
20953171	Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme Nakagawa, K, Hirota, Y, Sawada, N, Yuge, N, Watanabe, M, Uchino, Y, Okuda, N, Shimomura, Y, Suhara, Y, Okano, T	Nature	2010