UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

UBIAD1 (UbiA prenyltransferase domain-containing protein 1) in the endoplasmic reticulum catalyzes the transfer of a geranylgeranyl group from GGPP (geranylgeranyl pyrophosphate)to menadione to form MK4 (vitamin K hydroquinone, menatetrenone) (Nakagawa et al. 2010; Hirota et al. 2013, 2015; Schumacher et al. 2015).

Literature References
PubMed ID Title Journal Year
24085302 Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats

Suhara, Y, Tsugawa, N, Okano, T, Wada, A, Kamao, M, Uchino, Y, Sawada, N, Nakagawa, K, Tanaka, K, Takeuchi, A, Hirota, Y, Okitsu, T

J. Biol. Chem. 2013
25742604 The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase

Schumacher, MM, Jo, Y, DeBose-Boyd, RA, Seemann, J, Elsabrouty, R

Elife 2015
25874989 Functional characterization of the vitamin K2 biosynthetic enzyme UBIAD1

Tsugawa, N, Funahashi, N, Suhara, Y, Okano, T, Kamao, M, Uchino, Y, Kimoto, T, Okuda, N, Sawada, N, Nakagawa, K, Hirota, Y

PLoS ONE 2015
20953171 Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme

Suhara, Y, Okano, T, Shimomura, Y, Uchino, Y, Okuda, N, Sawada, N, Nakagawa, K, Yuge, N, Watanabe, M, Hirota, Y

Nature 2010
Catalyst Activity

prenyltransferase activity of UBIAD1 [endoplasmic reticulum membrane]

Orthologous Events
Cite Us!