Reactome | VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)

VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)

Stable Identifier

R-HSA-6806647

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

Synonyms

MK4 epoxide => MK4

ReviewStatus

5/5

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VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)

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VKORC1L1 (Vitamin K epoxide reductase complex subunit 1-like protein 1) in the endoplasmic reticulum catalyzes the reduction of MK4 epoxide to MK4, the active form of vitamin K. A physiological role for this reaction has not been established (Hammed et al. 2013; Tie et al. 2014; Westhofen et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21367861	Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function Westhofen, P, Watzka, M, Marinova, M, Hass, M, Kirfel, G, Müller, J, Bevans, CG, Müller, CR, Oldenburg, J	J. Biol. Chem.	2011
23928358	VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy Hammed, A, Matagrin, B, Spohn, G, Prouillac, C, Benoit, E, Lattard, V	J. Biol. Chem.	2013
24532791	Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration Tie, JK, Jin, DY, Stafford, DW	J. Biol. Chem.	2014