VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)

Stable Identifier
Reaction [transition]
Homo sapiens
MK4 epoxide => MK4
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VKORC1L1 (Vitamin K epoxide reductase complex subunit 1-like protein 1) in the endoplasmic reticulum catalyzes the reduction of MK4 epoxide to MK4, the active form of vitamin K. A physiological role for this reaction has not been established (Hammed et al. 2013; Tie et al. 2014; Westhofen et al. 2011).

Literature References
PubMed ID Title Journal Year
21367861 Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function

Bevans, CG, Oldenburg, J, Westhofen, P, Marinova, M, Watzka, M, Müller, CR, Kirfel, G, Müller, J, Hass, M

J. Biol. Chem. 2011
23928358 VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy

Matagrin, B, Lattard, V, Prouillac, C, Spohn, G, Hammed, A, Benoit, E

J. Biol. Chem. 2013
24532791 Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration

Stafford, DW, Jin, DY, Tie, JK

J. Biol. Chem. 2014
Catalyst Activity

vitamin-K-epoxide reductase (warfarin-sensitive) activity of VKORC1L1 [endoplasmic reticulum membrane]

Orthologous Events
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