Formation of tonofilament bundles

Stable Identifier
R-HSA-6806629
Type
Reaction [transition]
Species
Homo sapiens
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Keratin filaments are packed into bundles of varying diameter, called tonofilament bundles. These are the building blocks of the cytoskeleton in epithelial cells. Each bundle is surrounded by polyribosomes and multivesicular or folded membrane complexes that form a branched, tubular network (Norlen et al. 2003). In the stratum corneum, keratin bundles are thought to pack in a cubic rod pattern (Norlen & Al-Amoudi 2004). In living cells, X-ray diffraction studies of keratin intermediate filaments indicate a filament radius of 5 nm, hexagonal geometric arrangement with an interfilament distance of 14 nm and bundle diameters of 70 nm (Hémonnot et al. 2016).

Keratin filaments can rapidly disassemble and reassemble, allowing flexibility for the cytoskeleton. Keratin building blocks accumulate at the cell periphery near focal adhesions. Polymerization is regulated by signaling molecules, e.g. heat shock proteins, 14-3-3 proteins, kinases and phosphatases (Magin et al. 2007, Kayser et al. 2003).

Literature References
PubMed ID Title Journal Year
15373777 Stratum corneum keratin structure, function, and formation: the cubic rod-packing and membrane templating model

Norlén, L, Al-Amoudi, A

J. Invest. Dermatol. 2004
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