Keratin filament formation

Stable Identifier
R-HSA-6806610
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Keratin filament formation
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Mammalian keratin filaments are produced by the lateral and longitudinal aggregation of subunits, such as tetrameric protofilaments and octameric protofibrils (Aebi et al. 1983). The extent of aggregation depends on the pH and osmolarity of the surrounding cytoplasm (Yamada et al. 2002, Magin et al. 2007). Filaments have a cross-section of 32 keratin molecules (Jones et al. 1997).
Literature References
PubMed ID Title Journal Year
9468612 Intermediate filament structure: hard alpha-keratin

Parry, DA, Jones, LN, Steven, AC, Booy, FP, Watts, NR, Simon, M

Biophys. Chem. 1997
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Orthologous Events
Keratin filament formation (Bos taurus)
Keratin filament formation (Canis familiaris)
Keratin filament formation (Danio rerio)
Keratin filament formation (Gallus gallus)
Keratin filament formation (Mus musculus)
Keratin filament formation (Rattus norvegicus)
Keratin filament formation (Sus scrofa)
Keratin filament formation (Xenopus tropicalis)
Authored
Jupe, S  (2016-03-10)
Reviewed
Blumenberg, M  (2016-08-12)
Created
Jupe, S  (2015-10-23)
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