Keratin filament formation

Stable Identifier
R-HSA-6806610
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mammalian keratin filaments are produced by the lateral and longitudinal aggregation of subunits, such as tetrameric protofilaments and octameric protofibrils (Aebi et al. 1983). The extent of aggregation depends on the pH and osmolarity of the surrounding cytoplasm (Yamada et al. 2002, Magin et al. 2007). Filaments have a cross-section of 32 keratin molecules (Jones et al. 1997).

Literature References
PubMed ID Title Journal Year
9468612 Intermediate filament structure: hard alpha-keratin

Jones, LN, Simon, M, Watts, NR, Booy, FP, Steven, AC, Parry, DA

Biophys. Chem. 1997
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed
Created