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p-S15,S20-TP53 Tetramer:MLH1 Gene [nucleoplasm]
Stable Identifier
R-HSA-6806584
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
TP53 binds the MLH1 gene (Homo sapiens)
p-S15,S20-TP53 Tetramer:MLH1 Gene [nucleoplasm] (Homo sapiens)
TP53 stimulates MLH1 expression (Homo sapiens)
p-S15,S20-TP53 Tetramer:MLH1 Gene [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15781865
Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements
Sadowski, I
,
Chen, J
Proc. Natl. Acad. Sci. U.S.A.
2005
Participants
components
MLH1 Gene [nucleoplasm]
(Homo sapiens)
p-S15,S20-TP53 Tetramer [nucleoplasm]
(Homo sapiens)
Participates
as an output of
TP53 binds the MLH1 gene (Homo sapiens)
This entity regulates
Positively
TP53 stimulates MLH1 expression
(Homo sapiens)
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