TP53 stimulates PMS2 expression

Stable Identifier
R-HSA-6806405
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 stimulates PMS2 expression
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TP53 (p53) stimulates transcription of PMS2, involved in DNA mismatch repair, by binding to the p53 response element in the first intron of the PMS2 gene (Chen and Sadowski 2005).

Literature References
PubMed ID Title Journal Year
15781865 Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements

Sadowski, I, Chen, J

Proc. Natl. Acad. Sci. U.S.A. 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:PMS2 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-23)
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