TP53 stimulates MLH1 expression

Stable Identifier
R-HSA-6806392
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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TP53 stimulates MLH1 expression
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TP53 (p53) stimulates transcription of the MLH1 gene, involved in DNA mismatch repair, by binding to the p53 response element in the first intron of the MLH1 gene (Chen and Sadowski 2005).

Literature References
PubMed ID Title Journal Year
15781865 Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements

Sadowski, I, Chen, J

Proc. Natl. Acad. Sci. U.S.A. 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:MLH1 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-22)
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