TP53 stimulates MLH1 expression

Stable Identifier
R-HSA-6806392
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TP53 stimulates MLH1 expression
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TP53 (p53) stimulates transcription of the MLH1 gene, involved in DNA mismatch repair, by binding to the p53 response element in the first intron of the MLH1 gene (Chen and Sadowski 2005).

Literature References
PubMed ID Title Journal Year
15781865 Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements

Chen, J, Sadowski, I

Proc. Natl. Acad. Sci. U.S.A. 2005
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Positively by
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-23)
Cite Us!