Reactome | p-S291-PHF20 translocates to cytosol

p-S291-PHF20 translocates to cytosol

Stable Identifier

R-HSA-6805792

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        p-S291-PHF20 translocates to cytosol (Homo sapiens)

General

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PHF20 phosphorylated at serine S291 by AKT (Park et al. 2012, Li et al. 2013) translocates to the cytosol (Park et al. 2012). AKT thus prevents PHF20-mediated stimulation of TP53 (p53) activity (Park et al. 2012, Li et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
22975685	PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage Piao, L, Kim, Y, Kim, SH, Park, J, Brazil, DP, Hong, J, Park, J, Yoo, BC, Kong, G, Seok, JH, Choi, SW, Hur, GM, Park, KA, Zhang, T, Li, Y, Hemmings, BA	Cell. Signal.	2013
22334668	Identification of Akt interaction protein PHF20/TZP that transcriptionally regulates p53 Park, S, Testa, JR, Dan, HC, Chen, H, Cheng, JQ, Kim, D	J. Biol. Chem.	2012