Reactome | GPR45 [plasma membrane]

GPR45 [plasma membrane]

Stable Identifier

R-HSA-6805227

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Probable G-protein coupled receptor 45, GPR45_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR45 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR45 [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR45 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR45 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR45 [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR45 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y5Y3 GPR45

Gene Names

GPR45

Chain

chain:1-372

Reference Genes

BioGPS Gene:11250 GPR45

COSMIC (genes):GPR45 GPR45

CTD Gene:11250 GPR45

dbSNP Gene:11250 GPR45

ENSEMBL:ENSG00000135973 GPR45

HGNC:4503 GPR45

KEGG:hsa:11250 GPR45

Monarch:11250 GPR45

NCBI Gene:11250 GPR45

OMIM:604838 GPR45

UCSC:Q9Y5Y3 GPR45

Reference Transcript

RefSeq:NM_007227.3 GPR45

Other Identifiers

11250

11735781_at

16883886

211175_PM_at

211175_at

2497982

2497983

2497984

2497985

2497986

2497987

31334_at

8044124

A_14_P122771

A_14_P201885

A_23_P131534

GE484425

GO:0004930

GO:0005515

GO:0005886

GO:0007165

GO:0007186

GO:0016020

GO:0060089

HMNXSV003028388

ILMN_2052487

PH_hs_0007589

TC02000644.hg

g2735350_3p_at

Participates

as a member of

Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)

Inferred To

Gpr45 [plasma membrane] (Mus musculus)

Gpr45 [plasma membrane] (Rattus norvegicus)

gpr45 [plasma membrane] (Xenopus tropicalis)

GPR45 [plasma membrane] (Bos taurus)

GPR45 [plasma membrane] (Canis familiaris)

GPR45 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_009158.3

Guide to Pharmacology - Targets

106

ENSEMBL

ENSP00000258456, ENST00000258456

OpenTargets

ENSG00000135973

HPA

ENSG00000135973-GPR45

PRO

Q9Y5Y3

Pharos - Targets

Q9Y5Y3

GlyGen

Q9Y5Y3