Reactome | GPR25 [plasma membrane]

GPR25 [plasma membrane]

Stable Identifier

R-HSA-6805220

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Probable G-protein coupled receptor 25, GPR25_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR25 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR25 [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR25 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR25 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR25 [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR25 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00155 GPR25

Gene Names

GPR25

Chain

chain:1-361

Reference Genes

BioGPS Gene:2848 GPR25

COSMIC (genes):GPR25 GPR25

CTD Gene:2848 GPR25

dbSNP Gene:2848 GPR25

ENSEMBL:ENSG00000170128 GPR25

HGNC:4480 GPR25

KEGG:hsa:2848 GPR25

Monarch:2848 GPR25

NCBI Entrez Gene:2848 GPR25

OMIM:602174 GPR25

UCSC:O00155 GPR25

Reference Transcript

RefSeq:NM_005298.3 GPR25

Other Identifiers

11738099_at

16675695

221363_PM_x_at

221363_x_at

2374415

2374416

2374417

2374418

2374419

2848

7908637

ADDON000027.hg

A_23_P316531

GE793010

GO:0002376

GO:0004930

GO:0005515

GO:0005886

GO:0007165

GO:0007186

GO:0016020

GO:0016494

GO:0030595

GO:0048247

GO:0048870

GO:0070098

GO:0097021

HMNXSV003040538

ILMN_1761766

TC01001652.hg

g4885314_3p_at

Participates

as a member of

Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)

Inferred To

Homologues of GPR25 [plasma membrane] (Drosophila melanogaster)

Gpr25 [plasma membrane] (Mus musculus)

Gpr25 [plasma membrane] (Rattus norvegicus)

Tre1 [plasma membrane] (Drosophila melanogaster)

moody [plasma membrane] (Drosophila melanogaster)

gpr25 [plasma membrane] (Danio rerio)

GPR25 [plasma membrane] (Bos taurus)

GPR25 [plasma membrane] (Canis familiaris)

npr-25 [plasma membrane] (Caenorhabditis elegans)

EG:22E5.10 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_005289.2

Guide to Pharmacology - Targets

ENSEMBL

ENSG00000170128, ENST00000304244, ENSP00000301917

OpenTargets

ENSG00000170128

GeneCards

GPR25

HPA

ENSG00000170128-GPR25

PRO

O00155

Pharos - Targets

O00155

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.781	7
UniProt:Q9HD89 RETN	3	RETN [azurophil granule lumen] (R-HSA-6799357) RETN [extracellular region] (R-HSA-6806172) RETN [specific granule lumen] (R-HSA-6799355)	0.556	5
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:Q9UBD6 RHCG	1	RHCG [plasma membrane] (R-HSA-444397)	0.556	3
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.556	3
UniProt:P08034 GJB1	2	GJB1 [endoplasmic reticulum membrane] (R-HSA-190656) GJB1 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190636)	0.556	3
UniProt:Q68CJ9 CREB3L3	10	CREB3L3(1-?) [nucleoplasm] (R-HSA-6784629) CREB3L3(1-?) [cytosol] (R-HSA-6784654) CREB3L3 [endoplasmic reticulum membrane] (R-HSA-6784669) CREB3L3(?-461) [endoplasmic reticulum membrane] (R-HSA-6784710) CREB3L3 [Golgi membrane] (R-HSA-8874144) CREB3L3(365-461) [Golgi membrane] (R-HSA-8874130) CREB3L3(1-364) [Golgi membrane] (R-HSA-8874158) CREB3L3(1-323) [cytosol] (R-HSA-8874214) CREB3L3(1-323) [nucleoplasm] (R-HSA-8874217) CREB3L3(324-364) [Golgi membrane] (R-HSA-8874183)	0.556	3
UniProt:O15342 ATP6V0E1	3	ATP6V0E1 [endosome membrane] (R-HSA-912582) ATP6V0E1 [phagocytic vesicle membrane] (R-HSA-1222533) ATP6V0E1 [lysosomal membrane] (R-HSA-9640180)	0.556	3

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