Reactome | GPR20 [plasma membrane]

GPR20 [plasma membrane]

Stable Identifier

R-HSA-6805219

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G-protein coupled receptor 20, GPR20_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR20 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR20 [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR20 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR20 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR20 [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)
        
        GPR20 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99678 GPR20

Gene Names

GPR20

Chain

chain:1-358

Reference Genes

BioGPS Gene:2843 GPR20

COSMIC (genes):GPR20 GPR20

CTD Gene:2843 GPR20

dbSNP Gene:2843 GPR20

ENSEMBL:ENSG00000204882 GPR20

HGNC:4475 GPR20

KEGG:hsa:2843 GPR20

Monarch:2843 GPR20

NCBI Gene:2843 GPR20

OMIM:601908 GPR20

UCSC:Q99678 GPR20

Reference Transcript

RefSeq:NM_005293.2 GPR20

Other Identifiers

11740599_at

17081850

214510_PM_at

214510_at

2843

3156641

3156642

3156643

3156644

3156645

3156646

32351_at

8153269

A_23_P159237

A_24_P266466

GE81487

GO:0004930

GO:0005829

GO:0005886

GO:0007186

GO:0007200

GO:0016020

GO:0035025

GO:0043235

GO:0060089

HMNXSV003014917

Hs.188859.0.S1_3p_at

ILMN_1704464

PH_hs_0011064

TC08001694.hg

Participates

as a member of

Constitutively active orphan GPCRs [plasma membrane] (Homo sapiens)

Inferred To

Gpr20 [plasma membrane] (Mus musculus)

GPR20 [plasma membrane] (Bos taurus)

GPR20 [plasma membrane] (Canis familiaris)

GPR20 [plasma membrane] (Gallus gallus)

GPR20 [plasma membrane] (Sus scrofa)

gnrr-4 [plasma membrane] (Caenorhabditis elegans)

gpr20 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_005284.2

Guide to Pharmacology - Targets

ENSEMBL

ENST00000707609, ENST00000377741, ENSG00000291465, ENSP00000366970, ENST00000613887, ENSP00000479665, ENSP00000516924, ENSG00000275181, ENSG00000204882

OpenTargets

ENSG00000204882

GeneCards

GPR20

HPA

ENSG00000204882-GPR20

PRO

Q99678

Pharos - Targets

Q99678

GlyGen

Q99678

PDB

8HS2, 8HSC, 8HS3