GPR35 binds kynurenic acid

Stable Identifier
R-HSA-6805205
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GPR35 is expressed both in neurons and other cells (including glia, macrophages and monocytes). KYNA has been proposed as the endogenous agonist of GPR35 (Wang et al. 2006).

Kynurenic acid (KYNA) is a tryptophan metabolite (Moroni 1999). It can selectively antagonize NMDA type glutamate receptors (Perkins & Stone 1982).

Literature References
PubMed ID Title Journal Year
16754668 Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

Wang, J, Simonavicius, N, Wu, X, Swaminath, G, Reagan, J, Tian, H, Ling, L

J. Biol. Chem. 2006
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