Reactome | FIP1L1 [nucleoplasm]

FIP1L1 [nucleoplasm]

Stable Identifier

R-HSA-6805150

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Pre-mRNA 3'-end-processing factor FIP1, FIP1_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        FIP1L1 [nucleoplasm] (Homo sapiens)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        FIP1L1 [nucleoplasm] (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        FIP1L1 [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        FIP1L1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6UN15 FIP1L1

Gene Names

FIP1L1, FIP1, RHE

Chain

chain:1-594

Reference Genes

BioGPS Gene:81608 FIP1L1

COSMIC (genes):FIP1L1 FIP1L1

CTD Gene:81608 FIP1L1

dbSNP Gene:81608 FIP1L1

ENSEMBL:ENSG00000145216 FIP1L1

ENSEMBL:ENSG00000145216.17 FIP1L1

HGNC:19124 FIP1L1

KEGG Gene (Homo sapiens):81608 FIP1L1

Monarch:81608 FIP1L1

NCBI Gene:81608 FIP1L1

OMIM:607686 FIP1L1

UCSC:Q6UN15 FIP1L1

Reference Transcript

Other Identifiers

11743936_a_at

11751233_a_at

11759532_at

11759533_s_at

1554424_PM_at

1554424_at

16966748

221007_PM_s_at

221007_s_at

2727227

2727228

2727229

2727232

2727234

2727235

2727236

2727238

2727239

2727240

2727242

2727244

2727245

2727246

2727249

2727252

2727253

2727258

2727263

2727265

2727268

2727269

2727274

2727275

2727276

2727277

2727278

2727279

43072_s_at

58459_s_at

8095048

81608

A_23_P58337

A_24_P20623

A_24_P265162

GE83194

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0005847

GO:0006397

GO:0016071

GO:0043226

HMNXSV003001811

Hs.66295.2.A1_3p_at

Hs2.334812.2.S1_3p_s_at

ILMN_1768743

ILMN_2190942

PH_hs_0016478

TC04002930.hg

g13569873_3p_s_at

Participates

as a component of

CPSF [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol]

FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]

FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol]

FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]

FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]

p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]

p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]

p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]

Inferred To

fipp-1 [nucleoplasm] (Caenorhabditis elegans)

Fip1 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of FIP1L1 [nucleoplasm] (Bos taurus)

Ghost homologue of FIP1L1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of FIP1L1 [nucleoplasm] (Schizosaccharomyces pombe)

Fip1l1 [nucleoplasm] (Mus musculus)

Fip1l1 [nucleoplasm] (Rattus norvegicus)

fip1l1 [nucleoplasm] (Danio rerio)

fip1l1 [nucleoplasm] (Dictyostelium discoideum)

fip1l1 [nucleoplasm] (Xenopus tropicalis)

FIP1L1 [nucleoplasm] (Canis familiaris)

FIP1L1 [nucleoplasm] (Gallus gallus)

FIP1L1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_112179.2, NP_001128410.1, NP_001128409.1

OpenTargets

ENSG00000145216

GeneCards

Q6UN15

HPA

ENSG00000145216-FIP1L1

Ensembl

ENST00000507922, ENST00000358575, ENSP00000425456, ENSG00000145216, ENSP00000351383, ENSP00000302993, ENSP00000336752, ENST00000337488, ENST00000306932

PRO

Q6UN15

Pharos - Targets

Q6UN15

Orphanet

16051

PDB

7ZY4, 7K95, 7ZYH

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:O95639 CPSF4	1	CPSF4 [nucleoplasm] (R-HSA-169104)	0.547	2