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FIP1L1 [nucleoplasm]
Stable Identifier
R-HSA-6805150
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Pre-mRNA 3'-end-processing factor FIP1, FIP1_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Formation of the Cleavage and Polyadenylation Complex (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)
Transport of Mature mRNA Derived from an Intronless Transcript (Homo sapiens)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
Mature intronless derived mRNA complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
Processing of Capped Intronless Pre-mRNA (Homo sapiens)
Processing of Intronless Pre-mRNAs (Homo sapiens)
Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)
Mature intronless derived mRNA complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
Recognition of AAUAAA sequence by CPSF (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
Recruitment of CstF to the CPSF Bound Pre-mRNA (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
CPSF [nucleoplasm] (Homo sapiens)
FIP1L1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6UN15 FIP1L1
Gene Names
FIP1L1, FIP1, RHE
Chain
chain:1-594
Reference Genes
BioGPS Gene:81608 FIP1L1
COSMIC (genes):FIP1L1 FIP1L1
CTD Gene:81608 FIP1L1
dbSNP Gene:81608 FIP1L1
ENSEMBL:ENSG00000145216 FIP1L1
ENSEMBL_homo_sapiens_GENE:ENSG00000145216.17 FIP1L1
HGNC:19124 FIP1L1
KEGG Gene (Homo sapiens):81608 FIP1L1
Monarch:81608 FIP1L1
NCBI Gene:81608 FIP1L1
OMIM:607686 FIP1L1
UCSC:Q6UN15 FIP1L1
Reference Transcript
RefSeq:NM_001134938.1 FIP1L1
RefSeq:NM_030917.3 FIP1L1
RefSeq:NM_001134937.1 FIP1L1
Other Identifiers
11743936_a_at
11751233_a_at
11759532_at
11759533_s_at
1554424_PM_at
1554424_at
16966748
221007_PM_s_at
221007_s_at
227293_PM_at
227293_at
2727227
2727228
2727229
2727232
2727234
2727235
2727236
2727238
2727239
2727240
2727242
2727244
2727245
2727246
2727249
2727252
2727253
2727258
2727263
2727265
2727268
2727269
2727274
2727275
2727276
2727277
2727278
2727279
2727280
2727281
2727282
2727283
2727284
43072_s_at
44003_r_at
58459_s_at
60065_s_at
8095048
81608
A_23_P58337
A_24_P20623
A_24_P265162
GE83194
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0005847
GO:0006397
GO:0016071
GO:0043226
HMNXSV003001811
Hs.66295.2.A1_3p_at
Hs2.334812.2.S1_3p_s_at
ILMN_1768743
ILMN_2190942
PH_hs_0016478
TC04002930.hg
g13569873_3p_s_at
p28455
p28515
Participates
as a component of
CPSF [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol]
p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]
p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]
FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]
FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol]
FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]
FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]
p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]
Inferred To
fipp-1 [nucleoplasm]
(Caenorhabditis elegans)
Fip1 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of FIP1L1 [nucleoplasm]
(Saccharomyces cerevisiae)
Fip1l1 [nucleoplasm]
(Mus musculus)
Fip1l1 [nucleoplasm]
(Rattus norvegicus)
fip1l1 [nucleoplasm]
(Danio rerio)
fip1l1 [nucleoplasm]
(Dictyostelium discoideum)
fip1l1 [nucleoplasm]
(Xenopus tropicalis)
FIP1L1 [nucleoplasm]
(Bos taurus)
FIP1L1 [nucleoplasm]
(Canis familiaris)
FIP1L1 [nucleoplasm]
(Gallus gallus)
FIP1L1 [nucleoplasm]
(Schizosaccharomyces pombe)
FIP1L1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001128410.1
,
NP_001128409.1
,
NP_112179.2
OpenTargets
ENSG00000145216
HPA
ENSG00000145216-FIP1L1
GeneCards
Q6UN15
Ensembl
ENSP00000336752
,
ENSG00000145216
,
ENSP00000351383
,
ENSP00000515339
,
ENST00000703489
,
ENSP00000425456
,
ENST00000507922
,
ENST00000337488
,
ENSP00000302993
,
ENST00000358575
,
ENST00000306932
PRO
Q6UN15
Pharos - Targets
Q6UN15
Orphanet
16051
PDB
7K95
,
7ZY4
,
7ZYH
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95639 CPSF4
1
CPSF4 [nucleoplasm]
(R-HSA-169104)
0.659
5
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:P09651 HNRNPA1
2
HNRNPA1 [cytosol]
(R-HSA-9727902)
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
0.483
2
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