Reactome | AURKB binds TP53

AURKB binds TP53

Stable Identifier

R-HSA-6805122

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        AURKB binds TP53 (Homo sapiens)

General

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AURKB (Aurora kinase B) is recruited to TP53 (p53) through interaction with NOC2L (NIR) (Wu et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
20959462	Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression Wu, L, Ma, CA, Zhao, Y, Jain, A	J. Biol. Chem.	2011

Participants

Input

Output

AURKB:NOC2L:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

Regulation of TP53 Activity through Phosphorylation

Orthologous Events

AURKB binds TP53 (Danio rerio)

AURKB binds TP53 (Drosophila melanogaster)

AURKB binds TP53 (Mus musculus)

AURKB binds TP53 (Rattus norvegicus)

AURKB binds TP53 (Sus scrofa)

AURKB binds TP53 (Xenopus tropicalis)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-17)