Reactome | AURKB binds TP53

AURKB binds TP53

Stable Identifier

R-HSA-6805122

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        AURKB binds TP53 (Homo sapiens)

General

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AURKB (Aurora kinase B) is recruited to TP53 (p53) through interaction with NOC2L (NIR) (Wu et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
20959462	Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression Wu, L, Ma, CA, Zhao, Y, Jain, A	J. Biol. Chem.	2011