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p-S166,S188-MDM2 dimer [nucleoplasm]
Stable Identifier
R-HSA-6804933
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Stabilization of p53 (Homo sapiens)
MDM2 binds TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
MDM2 forms homo- or heterodimers (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
MDM2 ubiquitinates TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oncogene Induced Senescence (Homo sapiens)
MDM2 ubiquitinates TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF sequesters MDM2 (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
MDM2 ubiquitinates TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF sequesters MDM2 (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Methylation (Homo sapiens)
MDM2 ubiquitinates JMY (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
MDM2 ubiquitinates DYRK2 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
MDM2 binds TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
MDM2 forms homo- or heterodimers (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
MDM2 homodimers auto-ubiquitinate (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
MDM2 ubiquitinates TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
USP7 deubiquitinates MDM2 (Homo sapiens)
p-S166,S188-MDM2:(p-S166,S188-MDM2,p-S346,S367,S403-MDM4) [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF forms a ternary complex with MDM2 and TP53 (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF sequesters MDM2 (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
MDM2 binds RUNX3 (Homo sapiens)
RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
MDM2 polyubiquitinates RUNX3 (Homo sapiens)
RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
21986495
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage
Chen, L
,
Chen, J
,
Cheng, Q
,
Li, B
,
Cross, B
,
Li, Z
Mol. Cell. Biol.
2011
Participants
components
x 2
p-S166,S188-MDM2 [nucleoplasm]
(Homo sapiens)
Participates
as an input of
MDM2 binds RUNX3 (Homo sapiens)
MDM2 homodimers auto-ubiquitinate (Homo sapiens)
as an output of
MDM2 polyubiquitinates RUNX3 (Homo sapiens)
as a component of
RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] (Homo sapiens)
as a member of
p-S166,S188-MDM2:(p-S166,S188-MDM2,p-S346,S367,S403-MDM4) [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Homo sapiens)
Inferred To
p-S166,S188-MDM2 dimer [nucleoplasm]
(Bos taurus)
p-S166,S188-MDM2 dimer [nucleoplasm]
(Canis familiaris)
p-S166,S188-MDM2 dimer [nucleoplasm]
(Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm]
(Gallus gallus)
p-S166,S188-MDM2 dimer [nucleoplasm]
(Mus musculus)
p-S166,S188-MDM2 dimer [nucleoplasm]
(Rattus norvegicus)
p-S166,S188-MDM2 dimer [nucleoplasm]
(Sus scrofa)
p-S166,S188-MDM2 dimer [nucleoplasm]
(Xenopus tropicalis)
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