Reactome | UACA [cytosol]

UACA [cytosol]

Stable Identifier

R-HSA-6804636

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Uveal autoantigen with coiled-coil domains and ankyrin repeats, Nucling

Locations in the PathwayBrowser for interactor UniProt:Q96GS4 BORC6

Expand all

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Apoptotic factor-mediated response (Homo sapiens)
      - Cytochrome c-mediated apoptotic response (Homo sapiens)
        
        Formation of apoptosome (Homo sapiens)
        
        Regulation of the apoptosome activity (Homo sapiens)
        
        UACA binds apoptosome (Homo sapiens)
        
        UACA [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BZF9 UACA

Gene Names

UACA, KIAA1561

Chain

chain:1-1416

Reference Genes

BioGPS Gene:55075 UACA

COSMIC (genes):UACA UACA

CTD Gene:55075 UACA

dbSNP Gene:55075 UACA

ENSEMBL:ENSG00000137831 UACA

ENSEMBL_homo_sapiens_GENE:ENSG00000137831.15 UACA

HGNC:15947 UACA

KEGG Gene (Homo sapiens):55075 UACA

Monarch:55075 UACA

NCBI Gene:55075 UACA

OMIM:612516 UACA

UCSC:Q9BZF9 UACA

Reference Transcript

Other Identifiers

11729317_a_at

11729318_s_at

11733252_a_at

11763843_a_at

16811249

223279_PM_s_at

223279_s_at

236715_3p_x_at

236715_PM_x_at

236715_x_at

238868_PM_at

238868_at

3631395

3631396

3631398

3631399

3631400

3631401

3631402

3631405

3631408

3631409

3631412

3631413

3631414

3631417

3631420

3631421

3631422

3631423

3631428

3631429

3631431

3631432

3631437

3631439

3631441

3631443

3631444

3631445

3631460

3631461

3631462

45677_at

49078_at

55075

59858_at

60607_r_at

7990054

82945_at

A_23_P360340

A_24_P290585

A_24_P90774

A_33_P3323718

GE88692

GE890594

GO:0003674

GO:0003779

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0008092

GO:0008150

GO:0023052

GO:0043226

GO:0070062

GO:1901223

HMNXSV003027774

Hs.53810.0.A1_3p_x_at

Hs.98312.0.S1_3p_at

ILMN_1681497

ILMN_1703273

ILMN_1758209

PH_hs_0003453

TC15001612.hg

g12240160_3p_a_at

g12240160_3p_s_at

Participates

as a candidate of

RHOH effectors [cytosol] (Homo sapiens)

as a component of

UACA:apoptosome [cytosol] (Homo sapiens)

as an input of

UACA binds apoptosome (Homo sapiens)

Inferred To

Uaca [cytosol] (Mus musculus)

Uaca [cytosol] (Rattus norvegicus)

UACA [cytosol] (Bos taurus)

UACA [cytosol] (Caenorhabditis elegans)

UACA [cytosol] (Canis familiaris)

UACA [cytosol] (Gallus gallus)

UACA [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_060473.2, NP_001008225.1

OpenTargets

ENSG00000137831

HPA

ENSG00000137831-UACA

GeneCards

Q9BZF9

Ensembl

ENSP00000369319, ENST00000379983, ENSG00000137831, ENST00000322954, ENSP00000314556

PRO

Q9BZF9

Pharos - Targets

Q9BZF9

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.659	4
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.569	3
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.556	3
UniProt:Q86Z20 CC125			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.556	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.527	2
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.527	2
UniProt:Q6NT04 TIGD7			0.527	2
UniProt:Q9NQW6 ANLN	1	ANLN [cytosol] (R-HSA-9690261)	0.527	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.527	2
UniProt:Q96GS4 BORC6			0.527	4
UniProt:Q96PV4 PNMA5			0.527	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.527	2
UniProt:Q9NYP9 MIS18A	1	MIS18A [nucleoplasm] (R-HSA-606299)	0.527	2
UniProt:Q96JJ6 JPH4			0.527	2
UniProt:Q9NWT6 HIF1AN	1	HIF1AN [cytosol] (R-HSA-1234154)	0.508	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	13

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