Reactome | INTL1 binds bacterial glycans

INTL1 binds bacterial glycans

Stable Identifier

R-HSA-6804527

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, cell wall

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Intelectin-1 (INTL1) is a 120-kDa secretory lectin that recognizes multiple glycan epitopes found exclusively on microbes: beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, heptoses, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (Tsuji S et al. 2001; Wesener DA et al. 2015). These glycan residues are widely distributed in bacteria, including S. pneumoniae, Proteus mirabilis, Proteus vulgaris, Yersinia pestis and K. pneumoniae (Wesener DA et al. 2015). The 1.6-A-resolution crystal structure of human INTL1 complexed with beta-Galf suggests that INTL1 binds its carbohydrate ligands bearing terminal 1,2-diols through calcium ion-dependent coordination (Wesener DA et al. 2015).

Secreted INTL1 functions as a disulfide-linked trimer (Tsuji S et al., 2001; Tsuji S et al., 2007; Wesener DA et al., 2015).

Literature References

PubMed ID	Title	Journal	Year
11313366	Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall Tsuji, S, Uehori, J, Matsumoto, M, Suzuki, Y, Matsuhisa, A, Toyoshima, K, Seya, T	J. Biol. Chem.	2001
26148048	Recognition of microbial glycans by human intelectin-1 Wesener, DA, Wangkanont, K, McBride, R, Song, X, Kraft, MB, Hodges, HL, Zarling, LC, Splain, RA, Smith, DF, Cummings, RD, Paulson, JC, Forest, KT, Kiessling, LL	Nat. Struct. Mol. Biol.	2015