Reactome | RNF34 [nucleoplasm]

RNF34 [nucleoplasm]

Stable Identifier

R-HSA-6804442

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase RNF34, RNF34_HUMAN, CARP1, Caspases-8 and -10-associated RING finger protein 1, FYVE-RING finger protein Momo, RING finger protein 34, RING finger protein RIFF

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        RNF34 or RFFL ubiquitinates phosphorylated TP53 (Homo sapiens)
        
        RNF34,RFFL [nucleoplasm] (Homo sapiens)
        
        RNF34 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q969K3 RNF34

Gene Names

RNF34

Chain

chain:1-372

Reference Genes

BioGPS Gene:80196 RNF34

COSMIC (genes):RNF34 RNF34

CTD Gene:80196 RNF34

dbSNP Gene:80196 RNF34

ENSEMBL:ENSG00000170633 RNF34

HGNC:17297 RNF34

KEGG:hsa:80196 RNF34

Monarch:80196 RNF34

NCBI Gene:80196 RNF34

OMIM:608299 RNF34

UCSC:Q969K3 RNF34

Reference Transcript

Other Identifiers

11717384_a_at

11761046_at

16758107

219035_PM_s_at

219035_s_at

229855_PM_at

229855_at

3434824

3434825

3434832

3434833

3434834

3434836

3434837

3434838

3434839

3434840

3434841

3434842

3434843

3434844

3434847

3434851

3434852

3434853

3434854

3434857

46229_at

49580_at

49581_g_at

7959282

80196

A_14_P119505

A_14_P129025

A_23_P128396

A_24_P278839

GE87752

GO:0002039

GO:0002376

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006511

GO:0006915

GO:0008270

GO:0012505

GO:0016020

GO:0016567

GO:0016604

GO:0016607

GO:0016740

GO:0030163

GO:0031625

GO:0035872

GO:0043161

GO:0046872

GO:0061630

GO:0070417

GO:0070936

GO:0140096

GO:1901796

GO:1901797

GO:1901981

GO:1902042

GO:2000374

HMNXSV003015741

HMNXSV003025092

Hs.312840.0.A1_3p_at

ILMN_1682988

ILMN_1786039

ILMN_2398664

PH_hs_0029655

TC12000958.hg

g13376704_3p_s_at

Participates

as a member of

RNF34,RFFL [nucleoplasm] (Homo sapiens)

Other forms of this molecule

RNF34 [cytosol]

Inferred To

RNF34 [nucleoplasm] (Bos taurus)

RNF34 [nucleoplasm] (Canis familiaris)

RNF34 [nucleoplasm] (Sus scrofa)

Rnf34 [nucleoplasm] (Mus musculus)

Rnf34 [nucleoplasm] (Rattus norvegicus)

dRNF34 [nucleoplasm] (Drosophila melanogaster)

rnf34 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_054229254.1, NP_001381137.1, NP_079402.2, XP_054229255.1, NP_919247.1, NP_001243787.1

ENSEMBL

ENST00000392465, ENSG00000170633, ENST00000361234, ENSP00000355137, ENSP00000376258

OpenTargets

ENSG00000170633

GeneCards

RNF34

HPA

ENSG00000170633-RNF34

PRO

Q969K3

Pharos - Targets

Q969K3

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:Q01658 DR1	1	DR1 [nucleoplasm] (R-HSA-3662280)	0.556	3
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.527	2
UniProt:Q14790 CASP8	8	CASP8(1-479) [cytosol] (R-HSA-57031) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(1-374) [cytosol] (R-HSA-3465404)	0.508	3