POU4F2 (BRN3B), similarly to POU4F1 (BRN3A), forms a complex with TP53 (p53). The interaction involves the POU domain of POU4F2 and the DNA binding domain of TP53. In contrast to POU4F1, binding of POU4F2 to TP53 enhances TP53-mediated transcriptional induction of pro-apoptotic targets such as BAX (Budhram-Mahadeo et al. 2006), NOXA and PUMA (Budhram-Mahadeo et al. 2014). The pro-apoptotic action of the complex of POU4F2 and TP53 may control the fate of cardiomyocytes in injured heart (Budhram-Mahadeo et al. 2014).
Budhram-Mahadeo, V, Fujita, R, Bitsi, S, Sicard, P, Heads, R
Budhram-Mahadeo, VS, Bowen, S, Lee, S, Perez-Sanchez, C, Ensor, E, Morris, PJ, Latchman, DS
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