Reactome | PRMT5 binds TTC5

PRMT5 binds TTC5

Stable Identifier

R-HSA-6804379

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        PRMT5 binds TTC5 (Homo sapiens)

General

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TTC5 (Strap) recruits protein arginine methyltransferase PRMT5 to TP53 (p53) (Jansson et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
19011621	Arginine methylation regulates the p53 response Cho, EC, Edelmann, M, Jansson, M, La Thangue, NB, Durant, ST, Kessler, B, Sheahan, S	Nat. Cell Biol.	2008