Reactome | TP53 binds the complex of JMY, EP300 and TTC5

TP53 binds the complex of JMY, EP300 and TTC5

Stable Identifier

R-HSA-6804242

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        TP53 binds the complex of JMY, EP300 and TTC5 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

TP53 binds the complex of JMY, EP300 and TTC5

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The complex of JMY, EP300 (p300) and TTC5 (Strap) associates with stabilized TP53 (p53) and enhances transcription of pro-apoptotic TP53 targets, such as BAX (Shikama et al. 1999, Demonacos et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11511361	A TPR motif cofactor contributes to p300 activity in the p53 response Demonacos, C, Krstic-Demonacos, M, La Thangue, NB	Mol. Cell	2001
10518217	A novel cofactor for p300 that regulates the p53 response Shikama, N, Lee, CW, France, S, Delavaine, L, Lyon, J, Krstic-Demonacos, M, La Thangue, NB	Mol. Cell	1999
22362889	The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure Adams, CJ, Pike, AC, Maniam, S, Sharpe, TD, Coutts, AS, Knapp, S, La Thangue, NB, Bullock, AN	Proc. Natl. Acad. Sci. U.S.A.	2012