TP53 binds the complex of JMY, EP300 and TTC5

Stable Identifier
Reaction [binding]
Homo sapiens
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The complex of JMY, EP300 (p300) and TTC5 (Strap) associates with stabilized TP53 (p53) and enhances transcription of pro-apoptotic TP53 targets, such as BAX (Shikama et al. 1999, Demonacos et al. 2001).

Literature References
PubMed ID Title Journal Year
11511361 A TPR motif cofactor contributes to p300 activity in the p53 response

Demonacos, C, Krstic-Demonacos, M, La Thangue, NB

Mol. Cell 2001
10518217 A novel cofactor for p300 that regulates the p53 response

Shikama, N, Lee, CW, France, S, Delavaine, L, Lyon, J, Krstic-Demonacos, M, La Thangue, NB

Mol. Cell 1999
22362889 The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure

Adams, CJ, Pike, AC, Maniam, S, Sharpe, TD, Coutts, AS, Knapp, S, La Thangue, NB, Bullock, AN

Proc. Natl. Acad. Sci. U.S.A. 2012
Participant Of
Orthologous Events
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