TP53 binds the complex of JMY, EP300 and TTC5

Stable Identifier
R-HSA-6804242
Type
Reaction
Species
Homo sapiens
Compartment
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The complex of JMY, EP300 (p300) and TTC5 (Strap) associates with stabilized TP53 (p53) and enhances transcription of pro-apoptotic TP53 targets, such as BAX (Shikama et al. 1999, Demonacos et al. 2001).

Literature References
PubMed ID Title Journal Year
10518217 A novel cofactor for p300 that regulates the p53 response

France, S, Lyon, J, Delavaine, L, Shikama, N, Krstic-Demonacos, M, Lee, CW, La Thangue, NB

Mol. Cell 1999
11511361 A TPR motif cofactor contributes to p300 activity in the p53 response

Krstic-Demonacos, M, Demonacos, C, La Thangue, NB

Mol. Cell 2001
22362889 The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure

Coutts, AS, Sharpe, TD, Knapp, S, Adams, CJ, La Thangue, NB, Pike, AC, Maniam, S, Bullock, AN

Proc. Natl. Acad. Sci. U.S.A. 2012
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