Reactome | TP53 binds the complex of JMY, EP300 and TTC5

TP53 binds the complex of JMY, EP300 and TTC5

Stable Identifier

R-HSA-6804242

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        TP53 binds the complex of JMY, EP300 and TTC5 (Homo sapiens)

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TP53 binds the complex of JMY, EP300 and TTC5

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The complex of JMY, EP300 (p300) and TTC5 (Strap) associates with stabilized TP53 (p53) and enhances transcription of pro-apoptotic TP53 targets, such as BAX (Shikama et al. 1999, Demonacos et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
10518217	A novel cofactor for p300 that regulates the p53 response France, S, Lyon, J, Delavaine, L, Shikama, N, Krstic-Demonacos, M, Lee, CW, La Thangue, NB	Mol. Cell	1999
11511361	A TPR motif cofactor contributes to p300 activity in the p53 response Krstic-Demonacos, M, Demonacos, C, La Thangue, NB	Mol. Cell	2001
22362889	The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure Coutts, AS, Sharpe, TD, Knapp, S, Adams, CJ, La Thangue, NB, Pike, AC, Maniam, S, Bullock, AN	Proc. Natl. Acad. Sci. U.S.A.	2012