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PRDM1 [nucleoplasm]
Stable Identifier
R-HSA-6804199
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PR domain zinc finger protein 1, BLIMP1, Beta-interferon gene positive regulatory domain I-binding factor
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Expression (Homo sapiens)
PRDM1 binds the TP53 gene (Homo sapiens)
PRDM1 [nucleoplasm] (Homo sapiens)
PRDM1:TP53 Gene [nucleoplasm] (Homo sapiens)
PRDM1 [nucleoplasm] (Homo sapiens)
PRDM1 represses TP53 expression (Homo sapiens)
PRDM1 [nucleoplasm] (Homo sapiens)
PRDM1:TP53 Gene [nucleoplasm] (Homo sapiens)
PRDM1 [nucleoplasm] (Homo sapiens)
TP53 stimulates PRDM1 expression (Homo sapiens)
PRDM1 [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Specification of primordial germ cells (Homo sapiens)
Expression of NANOS3 in primordial germ cells (Homo sapiens)
SOX17:TFAP2C:PRDM1:NANOS3 gene [nucleoplasm] (Homo sapiens)
PRDM1 [nucleoplasm] (Homo sapiens)
Expression of PRDM1 in primordial germ cells (Homo sapiens)
PRDM1 [nucleoplasm] (Homo sapiens)
SOX17, TFAP2C, and PRDM1 (BLIMP1) bind the NANOS3 gene (Homo sapiens)
PRDM1 [nucleoplasm] (Homo sapiens)
SOX17:TFAP2C:PRDM1:NANOS3 gene [nucleoplasm] (Homo sapiens)
PRDM1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
STAT3 nuclear events downstream of ALK signaling (Homo sapiens)
PRDM1 gene expression downstream of ALK signaling (Homo sapiens)
PRDM1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75626 PRDM1
Gene Names
PRDM1, BLIMP1
Chain
chain:1-825
Reference Genes
BioGPS Gene:639 PRDM1
COSMIC (genes):PRDM1 PRDM1
CTD Gene:639 PRDM1
dbSNP Gene:639 PRDM1
ENSEMBL:ENSG00000057657 PRDM1
HGNC:9346 PRDM1
KEGG:hsa:639 PRDM1
Monarch:639 PRDM1
NCBI Gene:639 PRDM1
OMIM:603423 PRDM1
UCSC:O75626 PRDM1
Reference Transcript
RefSeq:NM_182907.2 PRDM1
RefSeq:XM_011536063.2 PRDM1
RefSeq:XM_017011187.1 PRDM1
RefSeq:NM_001198.3 PRDM1
Other Identifiers
11726217_a_at
11726218_a_at
11731942_a_at
11752207_a_at
17011279
217192_PM_s_at
217192_s_at
228964_PM_at
228964_at
2919670
2919671
2919691
2919692
2919693
2919694
2919695
2919697
2919698
2919703
2919704
2919705
2919707
2919708
2919709
2919711
2919712
2919713
2919714
2919716
2919717
2919718
2919719
31779_s_at
639
8121257
87673_at
A_14_P127459
A_14_P200886
A_23_P350451
A_33_P3342081
GE54738
GE678448
GE88378
GO:0000122
GO:0000976
GO:0000977
GO:0000978
GO:0001227
GO:0001701
GO:0001763
GO:0001822
GO:0001892
GO:0001893
GO:0002250
GO:0002376
GO:0003170
GO:0003279
GO:0003281
GO:0003677
GO:0003700
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006355
GO:0006357
GO:0007281
GO:0008168
GO:0009791
GO:0010467
GO:0010468
GO:0010628
GO:0010629
GO:0016740
GO:0022414
GO:0030154
GO:0032259
GO:0032823
GO:0033082
GO:0035904
GO:0042127
GO:0042462
GO:0043226
GO:0045087
GO:0045165
GO:0046872
GO:0048844
GO:0048856
GO:0048869
GO:0051136
GO:0060040
GO:0060576
GO:0060707
GO:0060976
GO:0098542
GO:0140110
GO:1990226
GO:1990654
GO:1990837
GO:1990841
HMNXSV003040545
Hs.158303.1.S1_3p_a_at
Hs.289088.2.A1_3p_at
ILMN_1655077
ILMN_2294784
ILMN_2298159
ILMN_2414165
PH_hs_0018581
TC06000844.hg
p14638
Participates
as an output of
Expression of PRDM1 in primordial germ cells (Homo sapiens)
PRDM1 gene expression downstream of ALK signaling (Homo sapiens)
TP53 stimulates PRDM1 expression (Homo sapiens)
as a component of
SOX17:TFAP2C:PRDM1:NANOS3 gene [nucleoplasm] (Homo sapiens)
PRDM1:TP53 Gene [nucleoplasm] (Homo sapiens)
as an input of
SOX17, TFAP2C, and PRDM1 (BLIMP1) bind the NANOS3 gene (Homo sapiens)
PRDM1 binds the TP53 gene (Homo sapiens)
Inferred To
PRDM1 [nucleoplasm]
(Bos taurus)
PRDM1 [nucleoplasm]
(Canis familiaris)
PRDM1 [nucleoplasm]
(Gallus gallus)
PRDM1 [nucleoplasm]
(Sus scrofa)
prdm1 [nucleoplasm]
(Xenopus tropicalis)
Blimp-1 [nucleoplasm]
(Drosophila melanogaster)
blmp-1 [nucleoplasm]
(Caenorhabditis elegans)
Prdm1 [nucleoplasm]
(Mus musculus)
Prdm1 [nucleoplasm]
(Rattus norvegicus)
prdm1a [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
XP_016866676.1
,
NP_001189.2
,
XP_011534365.1
,
NP_878911.1
ENSEMBL
ENST00000652320
,
ENSP00000498580
,
ENST00000369091
,
ENSP00000358087
,
ENSP00000498716
,
ENST00000369096
,
ENSP00000358092
,
ENSP00000358085
,
ENST00000369089
,
ENST00000651185
OpenTargets
ENSG00000057657
HPA
ENSG00000057657-PRDM1
PRO
O75626
Pharos - Targets
O75626
GlyGen
O75626
PDB
3DAL
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.524
2
UniProt:Q12857 NFIA
1
NFIA [nucleoplasm]
(R-HSA-60134)
0.471
2
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