Reactome | TP53 stimulates PRDM1 expression

TP53 stimulates PRDM1 expression

Stable Identifier

R-HSA-6804193

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Expression (Homo sapiens)
        
        TP53 stimulates PRDM1 expression (Homo sapiens)

General

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Binding of TP53 (p53) to the p53 response element in the third intron of the PRDM1 (BLIMP1) gene stimulates BLIMP1 transcription (Yan et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17264218	BLIMP1 regulates cell growth through repression of p53 transcription Lim, CA, Ng, HH, Jiang, J, Yan, J, Chin, KC, Wu, Q	Proc. Natl. Acad. Sci. U.S.A.	2007

Participants

Input

PRDM1 Gene [nucleoplasm] (Homo sapiens)

Output

PRDM1 [nucleoplasm] (Homo sapiens)

Participates

as an event of

Regulation of TP53 Expression (Homo sapiens)

This event is regulated

Positively by

Regulator

p-S15,S20-TP53:PRDM1 Gene [nucleoplasm] (Homo sapiens)

Active Unit

p-S15,S20-TP53 Tetramer [nucleoplasm]

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-09)

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