PRDM1 represses TP53 expression

Stable Identifier
R-HSA-6804188
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PRDM1 represses TP53 expression
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Binding of PRDM1 (BLIMP1) to the promoter region of the TP53 (p53) gene inhibits TP53 transcription (Yan et al. 2007) probably by inducing repressive methylation of the TP53 promoter (Weige et al. 2014).
Literature References
PubMed ID Title Journal Year
17264218 BLIMP1 regulates cell growth through repression of p53 transcription

Lim, CA, Ng, HH, Jiang, J, Yan, J, Chin, KC, Wu, Q

Proc. Natl. Acad. Sci. U.S.A. 2007
24743655 Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans

Wilkerson, B, Duff, K, Birtwistle, MR, Banister, CE, Cloessner, E, Creek, KE, Ji, H, Berrong, Z, Shtutman, M, Clendenning, M, Tidwell, J, Weige, CC, Mallick, H, Farrell, C, Buckhaults, PJ, Yi, N, Bunz, F

Mol. Cancer Res. 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PRDM1:TP53 Gene [nucleoplasm] (Homo sapiens)
Active Unit
PRDM1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-09)
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