PRDM1 represses TP53 expression

Stable Identifier
R-HSA-6804188
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of PRDM1 (BLIMP1) to the promoter region of the TP53 (p53) gene inhibits TP53 transcription (Yan et al. 2007) probably by inducing repressive methylation of the TP53 promoter (Weige et al. 2014).

Literature References
PubMed ID Title Journal Year
24743655 Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans

Weige, CC, Birtwistle, MR, Mallick, H, Yi, N, Berrong, Z, Cloessner, E, Duff, K, Tidwell, J, Clendenning, M, Wilkerson, B, Farrell, C, Bunz, F, Ji, H, Shtutman, M, Creek, KE, Banister, CE, Buckhaults, PJ

Mol. Cancer Res. 2014
17264218 BLIMP1 regulates cell growth through repression of p53 transcription

Yan, J, Jiang, J, Lim, CA, Wu, Q, Ng, HH, Chin, KC

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Participant Of
This event is regulated
Authored
Reviewed
Created