S-nitrosylation of cysteine residues in proteins by N2O3

Stable Identifier
Reaction [transition]
Homo sapiens
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S-nitrosylation (SNO) is a selective post-translational protein modification that is mediated by nitric oxide radicals. SNO involves the covalent attachment of nitric oxide (NO) to the sulfur atom of cysteine to produce an S-N=O adduct. SNO critically regulates protein activity, localization and stability (Broniowska KA & Hogg N 2012; Ali AA et al. 2013)

Literature References
PubMed ID Title Journal Year
23402389 The contribution of N2O3 to the cytotoxicity of the nitric oxide donor DETA/NO: an emerging role for S-nitrosylation

Ali, AA, Coulter, JA, Ogle, CH, Migaud, MM, Hirst, DG, Robson, T, McCarthy, HO

Biosci. Rep. 2013
22468855 The chemical biology of S-nitrosothiols

Broniowska, KA, Hogg, N

Antioxid. Redox Signal. 2012
17664129 Methods to detect nitric oxide and its metabolites in biological samples

Bryan, NS, Grisham, MB

Free Radic. Biol. Med. 2007
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