S-nitrosylation of cysteine residues in proteins by N2O3

Stable Identifier
R-HSA-6803978
Type
Reaction [transition]
Species
Homo sapiens
Compartment
phagocytic vesicle
ReviewStatus
5/5
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S-nitrosylation of cysteine residues in proteins by N2O3
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S-nitrosylation (SNO) is a selective post-translational protein modification that is mediated by nitric oxide radicals. SNO involves the covalent attachment of nitric oxide (NO) to the sulfur atom of cysteine to produce an S-N=O adduct. SNO critically regulates protein activity, localization and stability (Broniowska KA & Hogg N 2012; Ali AA et al. 2013)

Literature References
PubMed ID Title Journal Year
22468855 The chemical biology of S-nitrosothiols

Broniowska, KA, Hogg, N

Antioxid. Redox Signal. 2012
23402389 The contribution of N2O3 to the cytotoxicity of the nitric oxide donor DETA/NO: an emerging role for S-nitrosylation

Robson, T, Coulter, JA, Ali, AA, Migaud, MM, Ogle, CH, Hirst, DG, McCarthy, HO

Biosci. Rep. 2013
17664129 Methods to detect nitric oxide and its metabolites in biological samples

Bryan, NS, Grisham, MB

Free Radic. Biol. Med. 2007
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Event Information
Go Biological Process
peptidyl-cysteine S-nitrosylation (0018119)
Authored
Shamovsky, V  (2018-10-23)
Reviewed
Nüsse, O  (2018-11-07)
Created
Shamovsky, V  (2015-10-08)
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