TP53 stimulates RGCC expression

Stable Identifier
R-HSA-6803917
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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TP53 stimulates RGCC expression
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Binding of TP53 (p53) to the p53 response element in the second intron of the RGCC (RGC32) gene stimulates RGCC transcription. RGCC is implicated in cell cycle regulation, but the mechanism is unknown. RGCC can associate with PLK1, but the biological significance of this interaction has not been elucidated. The RGCC gene is frequently deleted and down-regulated in glioma (Saigusa et al. 2007). However, RGCC overexpression has been reported in several different tumor types (Fosbrink et al. 2005).
Literature References
PubMed ID Title Journal Year
17146433 RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest

Saigusa, K, Imoto, I, Tanikawa, C, Aoyagi, M, Ohno, K, Nakamura, Y, Inazawa, J

Oncogene 2007
15713436 Overexpression of RGC-32 in colon cancer and other tumors

Fosbrink, M, Cudrici, C, Niculescu, F, Badea, TC, David, S, Shamsuddin, A, Shin, ML, Rus, H

Exp. Mol. Pathol. 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:RGCC Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-07)
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