TP53 stimulates RGCC expression

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of TP53 (p53) to the p53 response element in the second intron of the RGCC (RGC32) gene stimulates RGCC transcription. RGCC is implicated in cell cycle regulation, but the mechanism is unknown. RGCC can associate with PLK1, but the biological significance of this interaction has not been elucidated. The RGCC gene is frequently deleted and down-regulated in glioma (Saigusa et al. 2007). However, RGCC overexpression has been reported in several different tumor types (Fosbrink et al. 2005).

Literature References
PubMed ID Title Journal Year
17146433 RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest

Saigusa, K, Tanikawa, C, Inazawa, J, Aoyagi, M, Nakamura, Y, Ohno, K, Imoto, I

Oncogene 2007
15713436 Overexpression of RGC-32 in colon cancer and other tumors

Shin, ML, Badea, TC, David, S, Shamsuddin, A, Fosbrink, M, Cudrici, C, Rus, H, Niculescu, F

Exp. Mol. Pathol. 2005
This event is regulated
Cite Us!