SFN dimer binds CDK1 and CCNB1

Stable Identifier
R-HSA-6803875
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SFN dimer binds CDK1 and CCNB1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SFN (14-3-3-sigma) dimer binds the complex of CCNB1 (cyclin B1) and CDK1 (Cdc2) in the cytosol and prevents the translocation of the CCNB1:CDK1 complex into the nucleus. This induces G2 cell cycle arrest as nuclear localization of the CCNB1:CDK1 complex is necessary for phosphorylation of nuclear target proteins that are needed for the G2/M transition (Chan et al. 1999).
Literature References
PubMed ID Title Journal Year
10524633 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

Vogelstein, B, Chan, TA, Lengauer, C, Kinzler, KW, Hermeking, H

Nature 1999
Participants
Input
Output
Participates
as an event of
Orthologous Events
SFN dimer binds CDK1 and CCNB1 (Bos taurus)
SFN dimer binds CDK1 and CCNB1 (Caenorhabditis elegans)
SFN dimer binds CDK1 and CCNB1 (Danio rerio)
SFN dimer binds CDK1 and CCNB1 (Drosophila melanogaster)
SFN dimer binds CDK1 and CCNB1 (Mus musculus)
SFN dimer binds CDK1 and CCNB1 (Rattus norvegicus)
SFN dimer binds CDK1 and CCNB1 (Sus scrofa)
SFN dimer binds CDK1 and CCNB1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-07)
Cite Us!