SFN dimer binds CDK1 and CCNB1

Stable Identifier
R-HSA-6803875
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SFN (14-3-3-sigma) dimer binds the complex of CCNB1 (cyclin B1) and CDK1 (Cdc2) in the cytosol and prevents the translocation of the CCNB1:CDK1 complex into the nucleus. This induces G2 cell cycle arrest as nuclear localization of the CCNB1:CDK1 complex is necessary for phosphorylation of nuclear target proteins that are needed for the G2/M transition (Chan et al. 1999).

Literature References
PubMed ID Title Journal Year
10524633 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

Chan, TA, Hermeking, H, Lengauer, C, Kinzler, KW, Vogelstein, B

Nature 1999
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