TP53 binds the SFN gene

Stable Identifier
R-HSA-6803858
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TP53 binds the SFN gene
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TP53 (p53) binds the p53 response element in the promoter region of the SFN (14-3-3 sigma) gene (Hermeking et al. 1997). Interaction between ZNF385A (HZF) and TP53 facilitates TP53 binding to the promoter of the SFN gene (Das et al. 2007).

Literature References
PubMed ID Title Journal Year
17719541 Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

Bernstein, A, Aaronson, SA, Kimura, Y, Raj, L, Lee, SW, Das, S, Zhao, B

Cell 2007
9659898 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression

Zhang, L, Polyak, K, He, TC, Vogelstein, B, Lengauer, C, Kinzler, KW, Hermeking, H, Thiagalingam, S

Mol. Cell 1997
Participants
Input
Output
Participates
as an event of
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-07)
Cite Us!