FGFR2c-specific alternative splicing produces FGFR2c transcript

Stable Identifier
R-HSA-6803838
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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FGFR2c-specific alternative splicing produces FGFR2c transcript
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In mesenchymal cells, FGFR2 IIIc exon splicing is favoured by the binding of PTB1 to intronic splice silencer (ISS) sequences 1 and 2 that flank the IIIb specific exon, and by the binding of hnRNPA1 to an exonic splicing silencer (ESS) within the IIIb specific exon (Del Gatto-Konczak et al, 1999; Carstens et al, 2000). Binding of these proteins to the nascent mRNA , which occurs in the context of a larger splicing complex, represses IIIb-specific alternative splicing and favours the formation of FGFR2 IIIc-specific mRNA.
Literature References
PubMed ID Title Journal Year
9858549 hnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer

Olive, M, Del Gatto-Konczak, F, Gesnel, MC, Breathnach, R

Mol. Cell. Biol. 1999
10982855 An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein

Garcia-Blanco, MA, Carstens, RP, Wagner, EJ

Mol. Cell. Biol. 2000
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
FGFR2 IIIb-specific splicing complex [nucleoplasm] (Homo sapiens)
Active Unit
HNRNPM [nucleoplasm]
TIA1/TIAL1 [nucleoplasm]
ESRP1 [nucleoplasm]
hnRNPH1:hnPNPF:RBFOX2 [nucleoplasm]
ESRP2 [nucleoplasm]
Positively by
Regulator
FGFR2 IIIc-specific splicing complex [nucleoplasm] (Homo sapiens)
Active Unit
HNRNPA1 [nucleoplasm]
PTBP1 [nucleoplasm]
Authored
Rothfels, K  (2015-10-07)
Reviewed
Grose, RP  (2016-01-06)
Created
Rothfels, K  (2015-10-07)
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