FGFR2c-specific alternative splicing produces FGFR2c transcript

Stable Identifier
Reaction [omitted]
Homo sapiens
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In mesenchymal cells, FGFR2 IIIc exon splicing is favoured by the binding of PTB1 to intronic splice silencer (ISS) sequences 1 and 2 that flank the IIIb specific exon, and by the binding of hnRNPA1 to an exonic splicing silencer (ESS) within the IIIb specific exon (Del Gatto-Konczak et al, 1999; Carstens et al, 2000). Binding of these proteins to the nascent mRNA , which occurs in the context of a larger splicing complex, represses IIIb-specific alternative splicing and favours the formation of FGFR2 IIIc-specific mRNA.

Literature References
PubMed ID Title Journal Year
9858549 hnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer

Olive, M, Del Gatto-Konczak, F, Gesnel, MC, Breathnach, R

Mol. Cell. Biol. 1999
10982855 An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein

Garcia-Blanco, MA, Carstens, RP, Wagner, EJ

Mol. Cell. Biol. 2000
This event is regulated
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