FGFR2c-specific alternative splicing produces FGFR2c transcript

Stable Identifier
R-HSA-6803838
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In mesenchymal cells, FGFR2 IIIc exon splicing is favoured by the binding of PTB1 to intronic splice silencer (ISS) sequences 1 and 2 that flank the IIIb specific exon, and by the binding of hnRNPA1 to an exonic splicing silencer (ESS) within the IIIb specific exon (Del Gatto-Konczak et al, 1999; Carstens et al, 2000). Binding of these proteins to the nascent mRNA , which occurs in the context of a larger splicing complex, represses IIIb-specific alternative splicing and favours the formation of FGFR2 IIIc-specific mRNA.

Literature References
PubMed ID Title Journal Year
10982855 An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein

Carstens, RP, Wagner, EJ, Garcia-Blanco, MA

Mol. Cell. Biol. 2000
9858549 hnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer

Del Gatto-Konczak, F, Olive, M, Gesnel, MC, Breathnach, R

Mol. Cell. Biol. 1999
Participants
Participant Of
This event is regulated
Authored
Reviewed
Created