Reactome | AMDHD2 [cytosol]

AMDHD2 [cytosol]

Stable Identifier

R-HSA-6803808

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

fullName evidence="3"Putative N-acetylglucosamine-6-phosphate deacetylase ecNumber evidence="3"3.5.1.25/ecNumber, NAGA_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q15645%20PCH2

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)
        
        AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA (Homo sapiens)
        
        AMDHD2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y303 AMDHD2

Gene Names

AMDHD2, CGI-14

Chain

chain:1-409

Reference Genes

BioGPS Gene:51005 AMDHD2

COSMIC (genes):AMDHD2 AMDHD2

CTD Gene:51005 AMDHD2

dbSNP Gene:51005 AMDHD2

ENSEMBL:ENSG00000162066 AMDHD2

ENSEMBL_homo_sapiens_GENE:ENSG00000162066.16 AMDHD2

HGNC:24262 AMDHD2

KEGG Gene (Homo sapiens):51005 AMDHD2

Monarch:51005 AMDHD2

NCBI Gene:51005 AMDHD2

UCSC:Q9Y303 AMDHD2

Reference Transcript

Other Identifiers

11736276_s_at

11744011_s_at

11744583_s_at

11748224_x_at

16815143

219082_PM_at

219082_at

227841_3p_at

227841_PM_at

227841_at

3644933

3644934

3644935

3644937

3644944

3644945

3644946

3644948

3644950

3644953

3644954

3644955

3644957

3644959

3644960

3644961

3644962

3644963

3644964

3644965

3644966

3644967

3644969

3644970

48700_at

51005

54270_at

61363_at

7992656

A_21_P0000011

A_23_P49351

A_24_P287785

GE88832

GO:0003824

GO:0005515

GO:0005634

GO:0005829

GO:0005975

GO:0006040

GO:0006044

GO:0006046

GO:0006048

GO:0008448

GO:0016787

GO:0016810

GO:0019262

GO:0043226

GO:0046872

GO:0047419

GO:0055086

GO:1901135

HMNXSV003022999

Hs.9204.1.S1_3p_at

Hs.9204.1.S1_3p_x_at

ILMN_1695759

PH_hs_0025286

PH_hs_0039062

TC16000076.hg

g7705595_3p_at

Inferred To

AMDHD2 [cytosol] (Bos taurus)

AMDHD2 [cytosol] (Caenorhabditis elegans)

AMDHD2 [cytosol] (Canis familiaris)

AMDHD2 [cytosol] (Danio rerio)

AMDHD2 [cytosol] (Drosophila melanogaster)

AMDHD2 [cytosol] (Gallus gallus)

AMDHD2 [cytosol] (Mus musculus)

AMDHD2 [cytosol] (Rattus norvegicus)

AMDHD2 [cytosol] (Sus scrofa)

AMDHD2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001139287.1, NP_001317378.1, NP_057028.2

OpenTargets

ENSG00000162066

ZINC - Substances

NAGA_HUMAN

ZINC target

Q9Y303

PRO

Q9Y303

PDB

7NUT, 7NUU

IntEnz

3.5.1.25

GeneCards

Q9Y303

HPA

ENSG00000162066-AMDHD2

Ensembl

ENST00000413459, ENSP00000391596, ENSP00000307481, ENSG00000162066, ENST00000302956, ENST00000293971, ENSP00000293971

Pharos - Targets

Q9Y303

ZINC - Predictions - Purchasable

NAGA_HUMAN

HMDB Protein

HMDBP03692

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TDQ7 GNPDA2	1	GNPDA2 [cytosol] (R-HSA-6799601)	0.666	4
UniProt:Q15645 PCH2			0.556	3