Reactome | NAGK [cytosol]

NAGK [cytosol]

Stable Identifier

R-HSA-6803742

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

N-acetyl-D-glucosamine kinase, NAGK_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)
        
        NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P (Homo sapiens)
        
        NAGK dimer [cytosol] (Homo sapiens)
        
        NAGK [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UJ70 NAGK

Gene Names

NAGK

Chain

initiator methionine:, chain:2-344

Reference Genes

BioGPS Gene:55577 NAGK

COSMIC (genes):NAGK NAGK

CTD Gene:55577 NAGK

dbSNP Gene:55577 NAGK

ENSEMBL:ENSG00000124357 NAGK

HGNC:17174 NAGK

KEGG:hsa:55577 NAGK

Monarch:55577 NAGK

NCBI Gene:55577 NAGK

OMIM:606828 NAGK

UCSC:Q9UJ70 NAGK

Reference Transcript

RefSeq:NM_017567.4 NAGK

Participates

as a component of

NAGK dimer [cytosol] (Homo sapiens)

Inferred To

Nagk [cytosol] (Drosophila melanogaster)

NAGK [cytosol] (Bos taurus)

NAGK [cytosol] (Caenorhabditis elegans)

NAGK [cytosol] (Canis familiaris)

NAGK [cytosol] (Gallus gallus)

NAGK [cytosol] (Mus musculus)

NAGK [cytosol] (Rattus norvegicus)

NAGK [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_060037.3

ENSEMBL

ENSP00000477639, ENSP00000244204, ENST00000244204, ENST00000613852, ENSG00000124357, ENSP00000389087, ENST00000455662

OpenTargets

ENSG00000124357

GeneCards

NAGK

HPA

ENSG00000124357-NAGK

PRO

Q9UJ70

Pharos - Targets

Q9UJ70

GlyGen

Q9UJ70

HMDB Protein

HMDBP01028

PDB

2CH6, 2CH5

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	5
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.556	3
UniProt:O95409 ZIC2	1	ZIC2 [nucleoplasm] (R-HSA-5216208)	0.527	2
UniProt:P33992 MCM5	1	MCM5 [nucleoplasm] (R-HSA-68551)	0.527	2
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.527	2
UniProt:Q99439 CNN2	3	CNN2 [specific granule lumen] (R-HSA-6799532) CNN2 [extracellular region] (R-HSA-6806300) CNN2 [tertiary granule lumen] (R-HSA-6800942)	0.527	2

Cite Us!