Reactome | TP53 stimulates ZNF385A transcription

TP53 stimulates ZNF385A transcription

Stable Identifier

R-HSA-6803437

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        TP53 stimulates ZNF385A transcription (Homo sapiens)

General

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Binding of TP53 (p53) to the p53 response element(s) in the promoter of the ZNF385A (HZF) gene stimulates ZNF385A transcription (Das et al. 2007). TP53-mediated induction of ZNF385A is conserved in mouse (Sugimoto et al. 2006, Das et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
16382142	Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by DNA damage Sugimoto, M, Gromley, A, Sherr, CJ	Mol. Cell. Biol.	2006
17719541	Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation Das, S, Raj, L, Zhao, B, Kimura, Y, Bernstein, A, Aaronson, SA, Lee, SW	Cell	2007