Reactome | Negative regulation by 'PCBP4:CDKN1A mRNA [cytosol]'

Negative regulation by 'PCBP4:CDKN1A mRNA [cytosol]'

Stable Identifier

R-HSA-6803416

Type

NegativeRegulation

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Transcriptional activation of p53 responsive genes (Homo sapiens)
        
        Transcriptional activation of cell cycle inhibitor p21 (Homo sapiens)
        
        PCBP4 modulates CDKN1A translation (Homo sapiens)
        
        PCBP4:CDKN1A mRNA [cytosol]

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - FOXO-mediated transcription (Homo sapiens)
      - FOXO-mediated transcription of cell cycle genes (Homo sapiens)
        
        PCBP4 modulates CDKN1A translation (Homo sapiens)
        
        PCBP4:CDKN1A mRNA [cytosol]
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
        
        PCBP4 modulates CDKN1A translation (Homo sapiens)
        
        PCBP4:CDKN1A mRNA [cytosol]

Regulation participants

Regulation type

NegativeRegulation

Regulated entity

PCBP4 modulates CDKN1A translation

Regulator

PCBP4:CDKN1A mRNA [cytosol]

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