Reactome | TP53 stimulates PCBP4 expression

TP53 stimulates PCBP4 expression

Stable Identifier

R-HSA-6803400

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
        
        TP53 stimulates PCBP4 expression (Homo sapiens)

General

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Binding of TP53 (p53) to two p53 response elements in the promoter of the PCBP4 (MCG10) gene stimulates PCBP4 transcription. PCBP4 has three K homology (KH) domains involved in RNA binding that can interact with a poly(C) sequence. PCBP4 binding destabilizes its targets, including CDKN1A (p21), thus favouring p53-dependent apoptosis over cell cycle arrest (Zhu and Chen 2000).

Literature References

PubMed ID	Title	Journal	Year
10891498	MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M Zhu, J, Chen, X	Mol. Cell. Biol.	2000