TP53 stimulates PCBP4 expression

Stable Identifier
R-HSA-6803400
Type
Reaction [omitted]
Species
Homo sapiens
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Binding of TP53 (p53) to two p53 response elements in the promoter of the PCBP4 (MCG10) gene stimulates PCBP4 transcription. PCBP4 has three K homology (KH) domains involved in RNA binding that can interact with a poly(C) sequence. PCBP4 binding destabilizes its targets, including CDKN1A (p21), thus favouring p53-dependent apoptosis over cell cycle arrest (Zhu and Chen 2000).

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