DCD forms oligomeric complex

Stable Identifier
R-HSA-6803104
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
DCD forms oligomeric complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
DCD peptide is initially monomeric when secreted in human sweat. In presence of a negatively charged bacterial membrane the cationic N-terminus of DCD gets attracted electrostatically (Paulmann M et al. 2012). Upon interaction with the bacterial membrane a change in the secondary structure from random coil to an alpha-helical conformation is induced. DCD-1(L) self-assembles into a higher oligomeric state which is stabilized by zinc ions. Subsequently, by oligomerization DCD is able to form ion channels in the bacterial membrane resulting in bacterial cell death ( (Paulmann M et al. 2012; Song C et al. 2013; Burian M & Schittek B 2015).
Literature References
PubMed ID Title Journal Year
23426625 Crystal structure and functional mechanism of a human antimicrobial membrane channel

Song, C, Weichbrodt, C, Salnikov, ES, Dynowski, M, Forsberg, BO, Bechinger, B, Steinem, C, de Groot, BL, Zachariae, U, Zeth, K

Proc. Natl. Acad. Sci. U.S.A. 2013
22262861 Structure-activity analysis of the dermcidin-derived peptide DCD-1L, an anionic antimicrobial peptide present in human sweat

Paulmann, M, Arnold, T, Linke, D, Özdirekcan, S, Kopp, A, Gutsmann, T, Kalbacher, H, Wanke, I, Schuenemann, VJ, Habeck, M, Bürck, J, Ulrich, AS, Schittek, B

J. Biol. Chem. 2012
25596890 The secrets of dermcidin action

Burian, M, Schittek, B

Int. J. Med. Microbiol. 2015
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Authored
Shamovsky, V  (2015-10-05)
Reviewed
Hains, DS  (2016-08-02)
Jupe, S  (2016-04-15)
Created
Shamovsky, V  (2015-10-04)
Cite Us!