DCD is processed into DCD(63-110)

Stable Identifier
R-HSA-6802999
Type
Reaction [omitted]
Species
Homo sapiens
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Dermcidin (DCD) is constitutively expressed in eccrine sweat glands, secreted into sweat and transported to the epidermal surface where it is proteolytically processed giving rise to several truncated DCD peptides (Schittek B et al. 2001; Rieg S et al. 2006). The processed forms such as the anionic DCD(63-110) (DCD-1L) and DCD(63-109) (DCD-1) possess antimicrobial activity against Gram-positive (Staphylococcus aureus, Enterococcus faecalis, Staphylococcus epidermidis, Listeria monocytogenes) and Gram-negative bacteria (Escherichia coli, Pseudomonas putida, Salmonella typhimurium) as well as Candida albicans (Cipakova I et al. 2006; Lai YP et al. 2005; Schittek B et al. 2001; Steffen H et al. 2006; Vuong C et al. 2004). The antimicrobial activity of DCD(63-110) (DCD-1L) is maintained over a broad pH range and at high salt concentrations that resemble the conditions in human sweat (Schittek B et al. 2001). DCD(63-110) was reported to interact with negatively charged bacterial phospholipids which lead to (Zn2+)-dependent formation of oligomeric complexes in the bacterial membrane, which subsequently lead to ion channel formation resulting in membrane depolarization and bacterial cell death (Paulmann M et al. 2012; Song C et al. 2013).

Literature References
PubMed ID Title Journal Year
22455996 The multiple facets of dermcidin in cell survival and host defense

Schittek, B

J Innate Immun 2012
16354654 Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L

Baechle, D, Flad, T, Cansier, A, Steffen, H, Schittek, B, Tolson, J, Herrmann, T, Dihazi, H, Beck, A, Mueller, GA, Mueller, M, Stevanovic, S, Garbe, C, Mueller, CA, Kalbacher, H

J. Biol. Chem. 2006
16374474 Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites

Rieg, S, Seeber, S, Steffen, H, Humeny, A, Kalbacher, H, Stevanovic, S, Kimura, A, Garbe, C, Schittek, B

J. Invest. Dermatol. 2006
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